Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR2 | Q92731 | 1/20 | 0.59 |
| ▸ | JAK2 | O60674 | 1/20 | 0.39 |
| ▸ | JAK1 | P23458 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 6/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.35 |
| ▸ | RAB9A | P51151 | 2/20 | 0.33 |
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | CTDSP1 | Q9GZU7 | 2/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | CASP3 | P42574 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.32 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.32 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | ATM | Q13315 | 1/20 | 0.32 |
| ▸ | THRB | P10828 | 1/20 | 0.32 |
| ▸ | SLC18A3 | Q16572 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18258349 | 0.84 | ESR2 (0.59) | ESR2JAK2JAK1MAPTALDH1A1 | |
| SCHEMBL1171537 | 0.81 | ESR2 (0.78) | ESR2JAK2JAK1MAPTALDH1A1 | |
| SCHEMBL4335569 | 0.78 | ESR2 (0.69) | ESR2MAPTALDH1A1LMNAL3MBTL1 | |
| SCHEMBL18257860 | 0.77 | ESR2 (0.82) | ESR2JAK2JAK1MAPTALDH1A1 | |
| SCHEMBL19853819 | 0.76 | ESR2 (0.70) | ESR2JAK2JAK1THRB | |
| SCHEMBL10188554 | 0.75 | ESR2 (1.00) | ESR2JAK2JAK1ALDH1A1KDM4E | |
| SCHEMBL28123495 | 0.72 | ESR2 (0.74) | ESR2JAK2JAK1MAPTALDH1A1 | |
| SCHEMBL13195339 | 0.72 | ESR2 (0.55) | ESR2ALDH1A1RAB9ALMNAKDM4E | |
| SCHEMBL3302628 | 0.71 | ESR2 (0.71) | ESR2JAK2JAK1MAPTALDH1A1 | |
| SCHEMBL20524183 | 0.70 | ESR2 (0.40) | ESR2RAB9ALMNAKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3071541-A1 | SUBSTITUTED (4'-HYDROXYPHENYL)CYCLOALKANE COMPOUNDS AND USES THEREOF AS SELECTIVE AGONISTS OF THE ESTROGEN RECEPTOR BETA ISOFORM | Marquette University (US) | 2016-09-28 | — | — | EP | disclosed |
| WO-2015077611-A1 | SUBSTITUTED (4'-HYDROXYPHENYL)CYCLOALKANE COMPOUNDS AND USES THEREOF AS SELECTIVE AGONISTS OF THE ESTROGEN RECEPTOR BETA ISOFORM | MARQUETTE UNIVERSITY (US) | 2015-05-28 | — | — | WO | disclosed |