Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.46 |
| ▸ | TP53 | P04637 | 1/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.46 |
| ▸ | PKM | P14618 | 1/20 | 0.44 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.41 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.40 |
| ▸ | EPAS1 | Q99814 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | APEX1 | P27695 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | RECQL | P46063 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | CA12 | O43570 | 1/20 | 0.38 |
| ▸ | CA1 | P00915 | 1/20 | 0.38 |
| ▸ | CA2 | P00918 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19419845 | 0.76 | CYP1A2 (0.47) | ALDH1A1SMN1; SMN2TSHRLMNAKCNH2 | |
| SCHEMBL2950137 | 0.74 | ALDH1A1 (0.57) | ALDH1A1SMN1; SMN2ALOX15AOC3LMNA | |
| SCHEMBL30778216 | 0.73 | MAPT (0.47) | ALDH1A1SMN1; SMN2ALOX15TP53CYP3A4 | |
| SCHEMBL20378505 | 0.72 | CA12 (0.46) | ALDH1A1SMN1; SMN2ALOX15TP53CYP3A4 | |
| SCHEMBL2609828 | 0.71 | ALDH1A1 (0.52) | ALDH1A1SMN1; SMN2ALOX15TP53CYP3A4 | |
| SCHEMBL957148 | 0.70 | KCNN4 (0.33) | SMN1; SMN2CYP3A4CYP1A1CYP1B1 | |
| SCHEMBL29810172 | 0.70 | ALDH1A1 (0.47) | ALDH1A1SMN1; SMN2ALOX15TP53CYP3A4 | |
| SCHEMBL24425881 | 0.68 | ALDH1A1 (0.53) | ALDH1A1SMN1; SMN2ALOX15TP53CYP3A4 | |
| SCHEMBL4905134 | 0.68 | ALDH1A1 (0.64) | ALDH1A1SMN1; SMN2ALOX15TP53CYP3A4 | |
| SCHEMBL812742 | 0.68 | CA1 (0.58) | ALDH1A1ALOX15AOC3LMNAAPEX1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3071541-B1 | SUBSTITUTED (4'-HYDROXYPHENYL)CYCLOALKANE COMPOUNDS AND USES THEREOF AS SELECTIVE AGONISTS OF THE ESTROGEN RECEPTOR BETA ISOFORM | UNIV MARQUETTE (US) | 2023-06-07 | — | — | EP | disclosed |
| US-10570077-B2 | Substituted (4'-hydroxyphenyl)cyclohexane compounds and uses thereof as selective agonists of the estrogen receptor beta isoform | MARQUETTE UNIVERSITY (US) | 2020-02-25 | — | — | US | disclosed |
| US-20160340279-A1 | SUBSTITUTED (4'-HYDROXYPHENYL)CYCLOAKLKANE COMPOUNDS AND USES THEREOF AS SELECTIVE AGONISTS OF THE ESTROGEN RECEPTOR BETA ISOFORM | MARQUETTE UNIVERSITY (US) | 2016-11-24 | — | — | US | disclosed |
| EP-3071541-A1 | SUBSTITUTED (4'-HYDROXYPHENYL)CYCLOALKANE COMPOUNDS AND USES THEREOF AS SELECTIVE AGONISTS OF THE ESTROGEN RECEPTOR BETA ISOFORM | Marquette University (US) | 2016-09-28 | — | — | EP | disclosed |
| WO-2015077611-A1 | SUBSTITUTED (4'-HYDROXYPHENYL)CYCLOALKANE COMPOUNDS AND USES THEREOF AS SELECTIVE AGONISTS OF THE ESTROGEN RECEPTOR BETA ISOFORM | MARQUETTE UNIVERSITY (US) | 2015-05-28 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160340279-A1 | SUBSTITUTED (4'-HYDROXYPHENYL)CYCLOAKLKANE COMPOUNDS AND USES THEREOF AS SELECTIVE AGONISTS OF THE ESTROGEN RECEPTOR BETA ISOFORM | ESR2, GPER1, ESRRG | ALDH1A1 1956/4885SMN1; SMN2 3526/4885ALOX15 1598/4885 |
| US-10570077-B2 | Substituted (4'-hydroxyphenyl)cyclohexane compounds and uses thereof as selective agonists of the estrogen receptor beta isoform | ESR2, GPER1, ESR1 | ALDH1A1 1172/4885SMN1; SMN2 3357/4885ALOX15 1225/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.