Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 20/20 | 1.00 |
| ▸ | KCNH2 | Q12809 | 4/20 | 1.00 |
| ▸ | JAK2 | O60674 | 1/20 | 0.74 |
| ▸ | LCK | P06239 | 1/20 | 0.74 |
| ▸ | YES1 | P07947 | 1/20 | 0.74 |
| ▸ | LYN | P07948 | 1/20 | 0.74 |
| ▸ | FGR | P09769 | 1/20 | 0.74 |
| ▸ | SRC | P12931 | 1/20 | 0.74 |
| ▸ | PRKCA | P17252 | 1/20 | 0.74 |
| ▸ | FLT3 | P36888 | 1/20 | 0.74 |
| ▸ | ZAP70 | P43403 | 1/20 | 0.74 |
| ▸ | MAP3K9 | P80192 | 1/20 | 0.74 |
| ▸ | PAK5 | Q9P286 | 1/20 | 0.74 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16743138 | 0.89 | SYK (0.80) | SYKKCNH2JAK2LCKYES1 | |
| SCHEMBL16743248 | 0.88 | SYK (0.79) | SYKKCNH2JAK2LCKYES1 | |
| SCHEMBL15910688 | 0.86 | SYK (0.75) | SYKKCNH2JAK2LCKYES1 | |
| SCHEMBL14956172 | 0.85 | SYK (1.00) | SYKKCNH2JAK2LCKYES1 | |
| SCHEMBL899872 | 0.85 | SYK (1.00) | SYKKCNH2JAK2LCKYES1 | |
| SCHEMBL13624896 | 0.85 | SYK (1.00) | SYKKCNH2JAK2LCKYES1 | |
| SCHEMBL1352147 | 0.85 | SYK (1.00) | SYKKCNH2JAK2LCKYES1 | |
| SCHEMBL900582 | 0.85 | SYK (1.00) | SYKKCNH2JAK2LCKYES1 | |
| SCHEMBL13624637 | 0.85 | SYK (0.74) | SYKKCNH2JAK2LCKYES1 | |
| SCHEMBL14977351 | 0.85 | SYK (1.00) | SYKKCNH2JAK2LCKYES1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9040530-B2 | 1,2,4-triazine-6-carboxamide kinase inhibitors | PORTOLA PHARMACEUTICALS, INC. (US) | 2015-05-26 | — | — | US | disclosed |
| US-9040530-B2 | 1,2,4-triazine-6-carboxamide kinase inhibitors | PORTOLA PHARMACEUTICALS, INC. (US) | 2015-05-26 | — | — | US | disclosed |