Predicted protein targets (top 2)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IMPDH2 | P12268 | 13/20 | 0.43 |
| ▸ | SYK | P43405 | 7/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16743332 | 0.93 | SYK (0.42) | IMPDH2SYK | |
| SCHEMBL16743339 | 0.91 | IMPDH2 (0.41) | IMPDH2SYK | |
| SCHEMBL16743329 | 0.90 | SYK (0.45) | IMPDH2SYK | |
| SCHEMBL16743593 | 0.83 | SYK (0.45) | SYK | |
| SCHEMBL16743281 | 0.82 | SYK (0.46) | SYK | |
| SCHEMBL16743295 | 0.80 | SYK (0.46) | SYK | |
| SCHEMBL16743604 | 0.80 | SYK (0.44) | SYK | |
| SCHEMBL16743319 | 0.80 | SYK (0.53) | SYK | |
| SCHEMBL16743587 | 0.79 | SYK (0.53) | SYK | |
| SCHEMBL16743254 | 0.78 | SYK (0.65) | SYK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9040530-B2 | 1,2,4-triazine-6-carboxamide kinase inhibitors | PORTOLA PHARMACEUTICALS, INC. (US) | 2015-05-26 | — | — | US | disclosed |
| US-9040530-B2 | 1,2,4-triazine-6-carboxamide kinase inhibitors | PORTOLA PHARMACEUTICALS, INC. (US) | 2015-05-26 | — | — | US | disclosed |