Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKT1 | P31749 | 16/20 | 0.37 |
| ▸ | AKT2 | P31751 | 9/20 | 0.37 |
| ▸ | AKT3 | Q9Y243 | 2/20 | 0.37 |
| ▸ | FECH | P22830 | 1/20 | 0.37 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2027997 | 0.90 | AKT1 (0.41) | AKT1AKT2AKT3FECHKCNH2 | |
| SCHEMBL2028406 | 0.90 | AKT1 (0.43) | AKT1AKT2AKT3FECHKCNH2 | |
| SCHEMBL9947605 | 0.85 | AKT1 (0.39) | AKT1AKT2AKT3FECHKCNH2 | |
| SCHEMBL2030075 | 0.85 | AKT1 (0.37) | AKT1AKT2AKT3FECHKCNH2 | |
| SCHEMBL1674693 | 0.84 | AKT1 (0.46) | AKT1AKT2AKT3FECHKCNH2 | |
| SCHEMBL3614614 | 0.84 | AKT1 (0.37) | AKT1AKT2AKT3FECHKCNH2 | |
| SCHEMBL10226590 | 0.83 | AKT1 (0.37) | AKT1AKT2AKT3FECHKCNH2 | |
| SCHEMBL3623778 | 0.81 | AKT1 (0.42) | AKT1AKT2AKT3FECHKCNH2 | |
| SCHEMBL2028502 | 0.79 | AKT1 (0.45) | AKT1AKT2AKT3FECHKCNH2 | |
| SCHEMBL4295111 | 0.78 | AKT1 (0.46) | AKT1AKT2AKT3FECHKCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110092511-A1 | INHIBITORS OF AKT ACTIVITY | MERCK SHARP & DOHME LLC | 2011-04-21 | — | — | US | disclosed |
| US-20100022573-A1 | INHIBITORS OF AKT ACTIVITY | MERCK SHARP & DOHME CORP. | 2010-01-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110092511-A1 | INHIBITORS OF AKT ACTIVITY | AKT1S1, AKT1, PIK3CA | AKT1 2/4885AKT2 5/4885AKT3 8/4885 |
| US-20100022573-A1 | INHIBITORS OF AKT ACTIVITY | PIK3CD, PIK3CA, PIK3CG | AKT1 12/4885AKT2 4/4885AKT3 8/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.