Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKT1 | P31749 | 18/20 | 0.39 |
| ▸ | AKT2 | P31751 | 10/20 | 0.39 |
| ▸ | AKT3 | Q9Y243 | 2/20 | 0.39 |
| ▸ | FECH | P22830 | 1/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10226590 | 0.92 | AKT1 (0.37) | AKT1AKT2AKT3FECHKCNH2 | |
| SCHEMBL4286303 | 0.90 | AKT1 (0.44) | AKT1AKT2AKT3FECHKCNH2 | |
| SCHEMBL4295111 | 0.90 | AKT1 (0.46) | AKT1AKT2AKT3FECHKCNH2 | |
| SCHEMBL3627805 | 0.88 | AKT1 (0.41) | AKT1AKT2AKT3FECHKCNH2 | |
| SCHEMBL1674693 | 0.87 | AKT1 (0.46) | AKT1AKT2AKT3FECHKCNH2 | |
| SCHEMBL1674497 | 0.85 | AKT1 (0.37) | AKT1AKT2AKT3FECHKCNH2 | |
| SCHEMBL3623778 | 0.84 | AKT1 (0.42) | AKT1AKT2AKT3FECHKCNH2 | |
| SCHEMBL4289993 | 0.84 | AKT1 (0.40) | AKT1AKT2AKT3FECHKCNH2 | |
| SCHEMBL10226683 | 0.83 | AKT1 (0.38) | AKT1AKT2AKT3FECHKCNH2 | |
| SCHEMBL12583525 | 0.82 | AKT1 (0.45) | AKT1AKT2AKT3FECHKCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2303269-B1 | INHIBITORS OF AKT ACTIVITY | MERCK SHARP & DOHME (US) | 2014-07-30 | — | — | EP | disclosed |
| US-8207169-B2 | Substituted [1,2,4]triazolo[4′,3′:1,6]pyrido[2,3-b]pyrazines of the formula D | MSD K.K. (JP) | 2012-06-26 | — | — | US | disclosed |