Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 4/20 | 0.37 |
| ▸ | MAPK11 | Q15759 | 3/20 | 0.37 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.37 |
| ▸ | RAF1 | P04049 | 1/20 | 0.37 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.37 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.37 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.36 |
| ▸ | JAK2 | O60674 | 1/20 | 0.36 |
| ▸ | ADORA2A | P29274 | 4/20 | 0.35 |
| ▸ | ADORA2B | P29275 | 4/20 | 0.35 |
| ▸ | ADORA1 | P30542 | 4/20 | 0.35 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | CDC7 | O00311 | 1/20 | 0.35 |
| ▸ | BRAF | P15056 | 1/20 | 0.34 |
| ▸ | XDH | P47989 | 1/20 | 0.34 |
| ▸ | GSK3B | P49841 | 5/20 | 0.34 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.33 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.33 |
| ▸ | CDK2 | P24941 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3464623 | 0.66 | MAPK14 (0.41) | MAPK14MAPK11MAPK13RAF1MAPK9 | |
| SCHEMBL13184087 | 0.65 | LRRK2 (0.38) | MAPK14MAPK11MAPK13RAF1MAPK9 | |
| SCHEMBL10987803 | 0.65 | CCNT1 (0.51) | MAPK14MAPK9MAPK10JAK2ADORA2A | |
| SCHEMBL3143657 | 0.65 | GSK3B (0.64) | CDC7GSK3B | |
| SCHEMBL3565612 | 0.64 | KDM4E (0.45) | MAPK10POLBGSK3B | |
| SCHEMBL3390495 | 0.64 | KMT2A (0.41) | POLBXDH | |
| SCHEMBL10848672 | 0.63 | CCNT1 (0.42) | MAPK14MAPK10JAK2ADORA2AADORA2B | |
| SCHEMBL30595872 | 0.62 | HSP90AA1 (0.52) | MAPK14MAPK11MAPK13RAF1MAPK9 | |
| SCHEMBL2814353 | 0.62 | HSP90AA1 (0.52) | MAPK14MAPK11MAPK13RAF1MAPK9 | |
| SCHEMBL10842976 | 0.62 | PDE3B (0.42) | MAPK14MAPK9MAPK10JAK2ADORA2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2305651-A1 | 2,3,6-trisubstituted-4-pyrimidone derivatives | Mitsubishi Tanabe Pharma Corporation (JP) | 2011-04-06 | — | — | EP | disclosed |