Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 1/20 | 0.66 |
| ▸ | JAK1 | P23458 | 1/20 | 0.66 |
| ▸ | TYK2 | P29597 | 1/20 | 0.66 |
| ▸ | JAK3 | P52333 | 1/20 | 0.66 |
| ▸ | SYK | P43405 | 10/20 | 0.53 |
| ▸ | AURKA | O14965 | 5/20 | 0.51 |
| ▸ | CAMK1D | Q8IU85 | 3/20 | 0.48 |
| ▸ | ZAP70 | P43403 | 2/20 | 0.48 |
| ▸ | PRKCE | Q02156 | 1/20 | 0.47 |
| ▸ | BTK | Q06187 | 1/20 | 0.47 |
| ▸ | ITK | Q08881 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | KIF11 | P52732 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15428599 | 0.91 | JAK2 (0.68) | JAK2JAK1TYK2JAK3AURKA | |
| SCHEMBL406802 | 0.85 | JAK2 (0.71) | JAK2JAK1TYK2JAK3SYK | |
| SCHEMBL13355521 | 0.84 | TYK2 (0.52) | JAK2JAK1TYK2JAK3SYK | |
| SCHEMBL10191608 | 0.81 | JAK2 (0.61) | JAK2JAK1TYK2JAK3 | |
| SCHEMBL406314 | 0.81 | JAK2 (0.61) | JAK2JAK1TYK2JAK3 | |
| SCHEMBL403558 | 0.80 | JAK2 (0.62) | JAK2JAK1TYK2JAK3 | |
| SCHEMBL404082 | 0.80 | JAK2 (1.00) | JAK2JAK1TYK2JAK3SYK | |
| SCHEMBL15428610 | 0.74 | JAK2 (0.49) | JAK2JAK1TYK2JAK3SYK | |
| SCHEMBL400136 | 0.73 | JAK2 (0.55) | JAK2JAK1TYK2JAK3 | |
| SCHEMBL402656 | 0.73 | RXFP1 (0.56) | JAK2JAK1TYK2JAK3AURKA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2348860-B1 | PYRAZOLOPYRIMIDINE JAK INHIBITOR COMPOUNDS AND METHODS | GENENTECH INC (US) | 2015-05-27 | — | — | EP | disclosed |