Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 8/20 | 0.61 |
| ▸ | JAK1 | P23458 | 3/20 | 0.61 |
| ▸ | TYK2 | P29597 | 3/20 | 0.61 |
| ▸ | JAK3 | P52333 | 3/20 | 0.61 |
| ▸ | NTRK1 | P04629 | 12/20 | 0.61 |
| ▸ | PIM1 | P11309 | 1/20 | 0.56 |
| ▸ | FLT3 | P36888 | 1/20 | 0.56 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.56 |
| ▸ | MAPT | P10636 | 2/20 | 0.52 |
| ▸ | LMNA | P02545 | 1/20 | 0.51 |
| ▸ | POLB | P06746 | 1/20 | 0.51 |
| ▸ | GPR52 | Q9Y2T5 | 1/20 | 0.50 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10191608 | 1.00 | JAK2 (0.61) | JAK2JAK1TYK2JAK3NTRK1 | |
| SCHEMBL403558 | 0.90 | JAK2 (0.62) | JAK2JAK1TYK2JAK3NTRK1 | |
| SCHEMBL15428599 | 0.83 | JAK2 (0.68) | JAK2JAK1TYK2JAK3PIM1 | |
| SCHEMBL16747660 | 0.81 | JAK2 (0.66) | JAK2JAK1TYK2JAK3 | |
| SCHEMBL406802 | 0.81 | JAK2 (0.71) | JAK2JAK1TYK2JAK3NTRK1 | |
| SCHEMBL402655 | 0.78 | NTRK1 (0.68) | JAK2JAK1TYK2JAK3NTRK1 | |
| SCHEMBL402226 | 0.77 | JAK2 (0.58) | JAK2JAK1TYK2JAK3NTRK1 | |
| SCHEMBL404578 | 0.77 | TGFBR1 (0.49) | JAK2JAK1TYK2JAK3NTRK1 | |
| SCHEMBL405829 | 0.76 | TGFBR1 (0.58) | JAK2JAK1TYK2JAK3NTRK1 | |
| SCHEMBL404082 | 0.76 | JAK2 (1.00) | JAK2JAK1TYK2JAK3FLT3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120022043-A1 | PYRAZOLOPYRIMIDINE JAK INHIBITOR COMPOUNDS AND METHODS | GENENTECH, INC. (US) | 2012-01-26 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120022043-A1 | PYRAZOLOPYRIMIDINE JAK INHIBITOR COMPOUNDS AND METHODS | JAK2, JAK1, JAK3 | JAK2 1/4885JAK1 2/4885TYK2 18/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.