Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CLK4 | Q9HAZ1 | 8/20 | 0.62 |
| ▸ | CLK1 | P49759 | 7/20 | 0.62 |
| ▸ | CLK2 | P49760 | 7/20 | 0.62 |
| ▸ | DYRK1B | Q9Y463 | 7/20 | 0.62 |
| ▸ | DYRK1A | Q13627 | 5/20 | 0.62 |
| ▸ | CLK3 | P49761 | 3/20 | 0.62 |
| ▸ | AURKA | O14965 | 1/20 | 0.50 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.50 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | HCAR3 | P49019 | 1/20 | 0.44 |
| ▸ | TNK2 | Q07912 | 4/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1675111 | 0.88 | CLK4 (0.57) | CLK4CLK1CLK2DYRK1BDYRK1A | |
| SCHEMBL1675215 | 0.85 | CLK4 (0.65) | CLK4CLK1CLK2DYRK1BDYRK1A | |
| SCHEMBL1675190 | 0.84 | CLK4 (0.63) | CLK4CLK1CLK2DYRK1BDYRK1A | |
| SCHEMBL1675210 | 0.78 | CLK4 (0.70) | CLK4CLK1CLK2DYRK1BDYRK1A | |
| SCHEMBL1674969 | 0.78 | CLK4 (0.68) | CLK4CLK1CLK2DYRK1BDYRK1A | |
| SCHEMBL1675200 | 0.77 | CLK4 (1.00) | CLK4CLK1CLK2DYRK1BDYRK1A | |
| SCHEMBL1675197 | 0.77 | CLK4 (1.00) | CLK4CLK1CLK2DYRK1BDYRK1A | |
| SCHEMBL14595538 | 0.76 | CLK1 (0.66) | CLK4CLK1CLK2DYRK1BDYRK1A | |
| SCHEMBL13283132 | 0.76 | CLK1 (0.66) | CLK4CLK1CLK2DYRK1BDYRK1A | |
| SCHEMBL1675211 | 0.76 | CLK4 (0.66) | CLK4CLK1CLK2DYRK1BDYRK1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011041655-A1 | QUINAZOLIN-4-AMINE DERIVATIVES; AND METHODS OF USE | THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) | 2011-04-07 | — | — | WO | claimed |
| WO-2011041655-A1 | QUINAZOLIN-4-AMINE DERIVATIVES; AND METHODS OF USE | THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) | 2011-04-07 | — | — | WO | disclosed |