Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CLK4 | Q9HAZ1 | 14/20 | 0.51 |
| ▸ | CLK1 | P49759 | 8/20 | 0.51 |
| ▸ | CLK2 | P49760 | 6/20 | 0.51 |
| ▸ | DYRK1B | Q9Y463 | 6/20 | 0.51 |
| ▸ | DYRK1A | Q13627 | 5/20 | 0.51 |
| ▸ | CDK2 | P24941 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 6/20 | 0.38 |
| ▸ | LMNA | P02545 | 6/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 4/20 | 0.38 |
| ▸ | TSHR | P16473 | 3/20 | 0.38 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 5/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | CASP1 | P29466 | 1/20 | 0.38 |
| ▸ | CASP7 | P55210 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1675230 | 0.92 | CLK4 (0.60) | CLK4CLK1CLK2DYRK1BDYRK1A | |
| SCHEMBL1675147 | 0.85 | CDK2 (0.48) | CLK4CLK1CLK2DYRK1BDYRK1A | |
| SCHEMBL1675010 | 0.82 | CLK4 (0.43) | CLK4CLK1CLK2DYRK1BDYRK1A | |
| SCHEMBL1675133 | 0.82 | CLK4 (0.60) | CLK4CLK1CLK2DYRK1BDYRK1A | |
| SCHEMBL1675146 | 0.82 | CLK4 (0.50) | CLK4CLK1CLK2DYRK1BDYRK1A | |
| SCHEMBL1675096 | 0.81 | CLK4 (0.49) | CLK4CLK1CLK2DYRK1BDYRK1A | |
| SCHEMBL1675179 | 0.81 | CLK4 (0.52) | CLK4CLK1CLK2DYRK1BDYRK1A | |
| SCHEMBL1675053 | 0.80 | CLK1 (0.64) | CLK4CLK1CLK2DYRK1BDYRK1A | |
| SCHEMBL1675291 | 0.79 | CLK4 (0.50) | CLK4CLK1CLK2DYRK1BDYRK1A | |
| SCHEMBL1675160 | 0.77 | CLK4 (0.71) | CLK4CLK1CLK2DYRK1BDYRK1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011041655-A1 | QUINAZOLIN-4-AMINE DERIVATIVES; AND METHODS OF USE | THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) | 2011-04-07 | — | — | WO | claimed |
| WO-2011041655-A1 | QUINAZOLIN-4-AMINE DERIVATIVES; AND METHODS OF USE | THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) | 2011-04-07 | — | — | WO | disclosed |