Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CLK4 | Q9HAZ1 | 13/20 | 0.50 |
| ▸ | CLK1 | P49759 | 7/20 | 0.50 |
| ▸ | CLK2 | P49760 | 6/20 | 0.50 |
| ▸ | DYRK1B | Q9Y463 | 6/20 | 0.50 |
| ▸ | DYRK1A | Q13627 | 4/20 | 0.49 |
| ▸ | CDK2 | P24941 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 6/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 6/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 5/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.36 |
| ▸ | ABL1 | P00519 | 1/20 | 0.36 |
| ▸ | EGFR | P00533 | 1/20 | 0.36 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.36 |
| ▸ | INSR | P06213 | 1/20 | 0.36 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.36 |
| ▸ | PLK1 | P53350 | 1/20 | 0.36 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.36 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.36 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1675133 | 0.87 | CLK4 (0.60) | CLK4CLK1CLK2DYRK1BDYRK1A | |
| SCHEMBL1675146 | 0.87 | CLK4 (0.50) | CLK4CLK1CLK2DYRK1BDYRK1A | |
| SCHEMBL1675053 | 0.86 | CLK1 (0.64) | CLK4CLK1CLK2DYRK1BDYRK1A | |
| SCHEMBL1675096 | 0.86 | CLK4 (0.49) | CLK4CLK1CLK2DYRK1BDYRK1A | |
| SCHEMBL1675221 | 0.82 | CLK1 (0.49) | CLK4CLK1CLK2DYRK1BDYRK1A | |
| SCHEMBL1675230 | 0.81 | CLK4 (0.60) | CLK4CLK1CLK2DYRK1BDYRK1A | |
| SCHEMBL1675012 | 0.79 | CLK4 (0.51) | CLK4CLK1CLK2DYRK1BDYRK1A | |
| SCHEMBL1675287 | 0.79 | CLK4 (0.79) | CLK4CLK1CLK2DYRK1BDYRK1A | |
| SCHEMBL1675147 | 0.78 | CDK2 (0.48) | CLK4CLK1CLK2DYRK1BDYRK1A | |
| SCHEMBL1675010 | 0.78 | CLK4 (0.43) | CLK4CLK1CLK2DYRK1BDYRK1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011041655-A1 | QUINAZOLIN-4-AMINE DERIVATIVES; AND METHODS OF USE | THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) | 2011-04-07 | — | — | WO | claimed |
| WO-2011041655-A1 | QUINAZOLIN-4-AMINE DERIVATIVES; AND METHODS OF USE | THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) | 2011-04-07 | — | — | WO | disclosed |