SCHEMBL1675015

SCHEMBL1675015

OCc1ccc(-c2ccc3ncnc(N4CCOCC4)c3c2)o1

nearest known ligand 0.68

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
PI4KB Q9UBF8 1/20 0.68
CLK4 Q9HAZ1 11/20 0.58
CYP3A4 P08684 8/20 0.58
MAPK1 P28482 7/20 0.58
HIF1A Q16665 7/20 0.58
LMNA P02545 7/20 0.58
CYP1A2 P05177 7/20 0.58
ALDH1A1 P00352 5/20 0.58
TSHR P16473 5/20 0.56
CYP2C19 P33261 5/20 0.56
CYP2D6 P10635 3/20 0.55
HSD17B10 Q99714 2/20 0.55
MEN1 O00255 2/20 0.54
KMT2A Q03164 2/20 0.54
USP2 O75604 2/20 0.54
TP53 P04637 2/20 0.53
ALOX15 P16050 1/20 0.53
PTK2 Q05397 1/20 0.51
CLK1 P49759 2/20 0.50
CLK2 P49760 2/20 0.50

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1675254 0.91 PI4KB (0.58) PI4KBCLK4CYP3A4MAPK1HIF1A
SCHEMBL1675061 0.82 CLK4 (0.59) PI4KBCLK4CYP3A4MAPK1HIF1A
SCHEMBL1675252 0.82 CLK4 (0.60) PI4KBCLK4CYP3A4MAPK1HIF1A
SCHEMBL29360509 0.81 PI4KB (1.00) PI4KBCLK4MAPK1ALDH1A1USP2
SCHEMBL4890645 0.81 PI4KB (1.00) PI4KBCLK4MAPK1ALDH1A1USP2
SCHEMBL1675100 0.79 CLK4 (0.55) PI4KBCLK4CYP3A4MAPK1HIF1A
SCHEMBL4357245 0.76 CLK4 (0.70) CLK4CYP3A4MAPK1HIF1ALMNA
SCHEMBL4351394 0.76 CYP3A4 (0.70) CLK4CYP3A4MAPK1HIF1ALMNA
SCHEMBL8408289 0.76 PI4KB (0.48) PI4KBMAPK1ALDH1A1TSHRHSD17B10
SCHEMBL13900561 0.75 CLK4 (0.58) PI4KBCLK4ALDH1A1TP53CLK1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2011041655-A1 QUINAZOLIN-4-AMINE DERIVATIVES; AND METHODS OF USE THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) 2011-04-07 WO claimed
WO-2011041655-A1 QUINAZOLIN-4-AMINE DERIVATIVES; AND METHODS OF USE THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) 2011-04-07 WO disclosed