Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CLK4 | Q9HAZ1 | 12/20 | 0.60 |
| ▸ | HIF1A | Q16665 | 10/20 | 0.60 |
| ▸ | MAPK1 | P28482 | 9/20 | 0.60 |
| ▸ | ALDH1A1 | P00352 | 9/20 | 0.60 |
| ▸ | TSHR | P16473 | 7/20 | 0.60 |
| ▸ | CYP2C19 | P33261 | 7/20 | 0.60 |
| ▸ | CYP3A4 | P08684 | 12/20 | 0.57 |
| ▸ | CYP1A2 | P05177 | 11/20 | 0.57 |
| ▸ | LMNA | P02545 | 9/20 | 0.57 |
| ▸ | MEN1 | O00255 | 4/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.57 |
| ▸ | TP53 | P04637 | 2/20 | 0.57 |
| ▸ | CYP2D6 | P10635 | 5/20 | 0.56 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.56 |
| ▸ | USP2 | O75604 | 5/20 | 0.55 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.54 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.49 |
| ▸ | PI4KB | Q9UBF8 | 1/20 | 0.48 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.47 |
| ▸ | GAK | O14976 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1675015 | 0.82 | PI4KB (0.68) | CLK4HIF1AMAPK1ALDH1A1TSHR | |
| SCHEMBL1675061 | 0.80 | CLK4 (0.59) | CLK4HIF1AMAPK1ALDH1A1TSHR | |
| SCHEMBL1675254 | 0.80 | PI4KB (0.58) | CLK4HIF1AMAPK1ALDH1A1TSHR | |
| SCHEMBL1675100 | 0.77 | CLK4 (0.55) | CLK4HIF1AMAPK1ALDH1A1TSHR | |
| SCHEMBL2726603 | 0.77 | SMN1; SMN2 (0.49) | CLK4MAPK1ALDH1A1TSHRCYP2C19 | |
| SCHEMBL4357245 | 0.74 | CLK4 (0.70) | CLK4HIF1AMAPK1ALDH1A1TSHR | |
| SCHEMBL4351394 | 0.74 | CYP3A4 (0.70) | CLK4HIF1AMAPK1ALDH1A1TSHR | |
| SCHEMBL4121396 | 0.74 | CLK4 (0.73) | CLK4HIF1AMAPK1ALDH1A1TSHR | |
| SCHEMBL14595182 | 0.73 | ALDH1A1 (0.65) | CLK4HIF1AMAPK1ALDH1A1TSHR | |
| SCHEMBL4355316 | 0.73 | GAK (0.83) | CLK4HIF1AMAPK1ALDH1A1TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011041655-A1 | QUINAZOLIN-4-AMINE DERIVATIVES; AND METHODS OF USE | THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) | 2011-04-07 | — | — | WO | claimed |
| WO-2011041655-A1 | QUINAZOLIN-4-AMINE DERIVATIVES; AND METHODS OF USE | THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) | 2011-04-07 | — | — | WO | disclosed |