Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FER | P16591 | 13/20 | 0.54 |
| ▸ | SYK | P43405 | 6/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.47 |
| ▸ | CDC7 | O00311 | 1/20 | 0.47 |
| ▸ | PLK4 | O00444 | 1/20 | 0.47 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.47 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.47 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.47 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.47 |
| ▸ | JAK2 | O60674 | 1/20 | 0.47 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.47 |
| ▸ | RPS6KA5 | O75582 | 1/20 | 0.47 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.47 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.47 |
| ▸ | PAK4 | O96013 | 1/20 | 0.47 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.47 |
| ▸ | ABL1 | P00519 | 1/20 | 0.47 |
| ▸ | PRKCG | P05129 | 1/20 | 0.47 |
| ▸ | LCK | P06239 | 1/20 | 0.47 |
| ▸ | FYN | P06241 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1989066 | 0.93 | FER (0.51) | FERSYKMAPK1CDC7PLK4 | |
| SCHEMBL16976692 | 0.88 | FER (0.42) | FERSYKMAPK1CDC7PLK4 | |
| SCHEMBL16751294 | 0.86 | FER (0.40) | FERSYKMAPK1CDC7PLK4 | |
| SCHEMBL12564648 | 0.84 | SYK (0.56) | FERSYKMAPK1CDC7PLK4 | |
| SCHEMBL1985438 | 0.84 | SYK (0.56) | FERSYKMAPK1CDC7PLK4 | |
| SCHEMBL1985436 | 0.84 | SYK (0.56) | FERSYKMAPK1CDC7PLK4 | |
| SCHEMBL16751292 | 0.83 | ALDH1A1 (0.40) | FERSYKMAPK1CDC7ROCK2 | |
| SCHEMBL21031802 | 0.82 | SYK (0.43) | FERSYKJAK2ROCK2MAP4K4 | |
| SCHEMBL1990157 | 0.82 | SYK (0.53) | FERSYKMAPK1CDC7PLK4 | |
| SCHEMBL21032636 | 0.82 | SYK (0.53) | FERSYKMAPK1CDC7PLK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2902392-A1 | Fused heteroaromatic pyrrolidinones as syk inhibitors | Takeda Pharmaceutical Company Limited (JP) | 2015-08-05 | — | — | EP | disclosed |
| EP-2516434-B1 | FUSED HETEROAROMATIC PYRROLIDINONES AS SYK INHIBITORS | TAKEDA PHARMACEUTICAL (JP) | 2015-05-27 | — | — | EP | disclosed |