Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CLK4 | Q9HAZ1 | 16/20 | 0.44 |
| ▸ | CLK1 | P49759 | 8/20 | 0.44 |
| ▸ | CLK2 | P49760 | 7/20 | 0.44 |
| ▸ | DYRK1B | Q9Y463 | 7/20 | 0.44 |
| ▸ | DYRK1A | Q13627 | 6/20 | 0.44 |
| ▸ | CLK3 | P49761 | 3/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 11/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 10/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 7/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 7/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.38 |
| ▸ | TSHR | P16473 | 6/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 5/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.38 |
| ▸ | PIK3C2B | O00750 | 1/20 | 0.37 |
| ▸ | PIK3C2G | O75747 | 1/20 | 0.37 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.37 |
| ▸ | MAP2K5 | Q13163 | 1/20 | 0.37 |
| ▸ | MAP3K19 | Q56UN5 | 1/20 | 0.37 |
| ▸ | PIP4K2C | Q8TBX8 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1675083 | 0.85 | CLK4 (0.61) | CLK4CLK1CLK2DYRK1BDYRK1A | |
| SCHEMBL1675105 | 0.85 | CLK4 (0.48) | CLK4CLK1CLK2DYRK1BDYRK1A | |
| SCHEMBL1675109 | 0.84 | CLK4 (0.49) | CLK4CLK1CLK2DYRK1BDYRK1A | |
| SCHEMBL1675179 | 0.84 | CLK4 (0.52) | CLK4CLK1CLK2DYRK1BDYRK1A | |
| SCHEMBL1675151 | 0.80 | CLK4 (0.46) | CLK4CLK1CLK2DYRK1BDYRK1A | |
| SCHEMBL1675010 | 0.80 | CLK4 (0.43) | CLK4CLK1CLK2DYRK1BDYRK1A | |
| SCHEMBL1675221 | 0.79 | CLK1 (0.49) | CLK4CLK1CLK2DYRK1BDYRK1A | |
| SCHEMBL1675097 | 0.76 | CLK4 (0.77) | CLK4CLK1CLK2DYRK1BDYRK1A | |
| SCHEMBL1675187 | 0.71 | CLK4 (0.39) | CLK4CLK1CLK2DYRK1BDYRK1A | |
| SCHEMBL1675201 | 0.70 | CLK4 (0.67) | CLK4CLK1CLK2DYRK1BDYRK1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011041655-A1 | QUINAZOLIN-4-AMINE DERIVATIVES; AND METHODS OF USE | THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) | 2011-04-07 | — | — | WO | claimed |
| WO-2011041655-A1 | QUINAZOLIN-4-AMINE DERIVATIVES; AND METHODS OF USE | THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) | 2011-04-07 | — | — | WO | disclosed |