Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CLK1 | P49759 | 10/20 | 0.49 |
| ▸ | CLK4 | Q9HAZ1 | 13/20 | 0.43 |
| ▸ | CLK2 | P49760 | 9/20 | 0.43 |
| ▸ | DYRK1B | Q9Y463 | 9/20 | 0.43 |
| ▸ | DYRK1A | Q13627 | 8/20 | 0.43 |
| ▸ | CLK3 | P49761 | 2/20 | 0.41 |
| ▸ | MGAM | O43451 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | SI | P14410 | 1/20 | 0.36 |
| ▸ | MGAM2 | Q2M2H8 | 1/20 | 0.36 |
| ▸ | PIK3C2B | O00750 | 1/20 | 0.35 |
| ▸ | PIK3C2G | O75747 | 1/20 | 0.35 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.35 |
| ▸ | MAP2K5 | Q13163 | 1/20 | 0.35 |
| ▸ | MAP3K19 | Q56UN5 | 1/20 | 0.35 |
| ▸ | PIP4K2C | Q8TBX8 | 1/20 | 0.35 |
| ▸ | MAPK15 | Q8TD08 | 1/20 | 0.35 |
| ▸ | DYRK2 | Q92630 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1675109 | 0.88 | CLK4 (0.49) | CLK1CLK4CLK2DYRK1BDYRK1A | |
| SCHEMBL1675291 | 0.82 | CLK4 (0.50) | CLK1CLK4CLK2DYRK1BDYRK1A | |
| SCHEMBL1675083 | 0.82 | CLK4 (0.61) | CLK1CLK4CLK2DYRK1BDYRK1A | |
| SCHEMBL1675179 | 0.81 | CLK4 (0.52) | CLK1CLK4CLK2DYRK1BDYRK1A | |
| SCHEMBL1675219 | 0.80 | CLK4 (0.57) | CLK1CLK4CLK2DYRK1BDYRK1A | |
| SCHEMBL1675178 | 0.79 | CLK4 (0.44) | CLK1CLK4CLK2DYRK1BDYRK1A | |
| SCHEMBL1675112 | 0.75 | CLK1 (0.44) | CLK1CLK4CLK2DYRK1BDYRK1A | |
| SCHEMBL1675222 | 0.73 | CLK1 (0.67) | CLK1CLK4CLK2DYRK1BDYRK1A | |
| SCHEMBL1675128 | 0.72 | CLK4 (0.61) | CLK1CLK4CLK2DYRK1BDYRK1A | |
| SCHEMBL1675232 | 0.71 | CLK4 (0.66) | CLK1CLK4CLK2DYRK1BDYRK1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011041655-A1 | QUINAZOLIN-4-AMINE DERIVATIVES; AND METHODS OF USE | THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) | 2011-04-07 | — | — | WO | claimed |
| WO-2011041655-A1 | QUINAZOLIN-4-AMINE DERIVATIVES; AND METHODS OF USE | THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) | 2011-04-07 | — | — | WO | disclosed |