Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CLK4 | Q9HAZ1 | 14/20 | 0.73 |
| ▸ | CLK1 | P49759 | 9/20 | 0.73 |
| ▸ | CLK2 | P49760 | 6/20 | 0.73 |
| ▸ | DYRK1B | Q9Y463 | 6/20 | 0.73 |
| ▸ | DYRK1A | Q13627 | 6/20 | 0.73 |
| ▸ | CLK3 | P49761 | 1/20 | 0.57 |
| ▸ | PIP4K2C | Q8TBX8 | 1/20 | 0.57 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.57 |
| ▸ | PDE5A | O76074 | 1/20 | 0.47 |
| ▸ | ERN1 | O75460 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1675337 | 0.84 | CLK4 (1.00) | CLK4CLK1CLK2DYRK1BDYRK1A | |
| SCHEMBL1675054 | 0.83 | CLK4 (1.00) | CLK4CLK1CLK2DYRK1BDYRK1A | |
| SCHEMBL1675225 | 0.83 | CLK4 (0.69) | CLK4CLK1CLK2DYRK1BDYRK1A | |
| SCHEMBL1675116 | 0.80 | CLK4 (0.72) | CLK4CLK1CLK2DYRK1BDYRK1A | |
| SCHEMBL1675222 | 0.79 | CLK1 (0.67) | CLK4CLK1CLK2DYRK1BDYRK1A | |
| SCHEMBL1675185 | 0.77 | CLK4 (0.65) | CLK4CLK1CLK2DYRK1BDYRK1A | |
| SCHEMBL1675107 | 0.76 | CLK4 (0.70) | CLK4CLK1CLK2DYRK1BDYRK1A | |
| SCHEMBL1675219 | 0.75 | CLK4 (0.57) | CLK4CLK1CLK2DYRK1BDYRK1A | |
| SCHEMBL1675127 | 0.74 | CLK1 (1.00) | CLK4CLK1CLK2DYRK1BDYRK1A | |
| SCHEMBL1675006 | 0.74 | CLK1 (0.71) | CLK4CLK1CLK2DYRK1BDYRK1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011041655-A1 | QUINAZOLIN-4-AMINE DERIVATIVES; AND METHODS OF USE | THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) | 2011-04-07 | — | — | WO | claimed |
| WO-2011041655-A1 | QUINAZOLIN-4-AMINE DERIVATIVES; AND METHODS OF USE | THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) | 2011-04-07 | — | — | WO | disclosed |