Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CLK1 | P49759 | 5/20 | 0.71 |
| ▸ | CLK4 | Q9HAZ1 | 17/20 | 0.66 |
| ▸ | DYRK1A | Q13627 | 4/20 | 0.66 |
| ▸ | CLK2 | P49760 | 2/20 | 0.66 |
| ▸ | CLK3 | P49761 | 2/20 | 0.66 |
| ▸ | DYRK1B | Q9Y463 | 2/20 | 0.66 |
| ▸ | PIP4K2C | Q8TBX8 | 1/20 | 0.66 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.66 |
| ▸ | CYP1A2 | P05177 | 5/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 5/20 | 0.50 |
| ▸ | CYP2D6 | P10635 | 5/20 | 0.50 |
| ▸ | TSHR | P16473 | 5/20 | 0.50 |
| ▸ | LMNA | P02545 | 5/20 | 0.50 |
| ▸ | CYP2C19 | P33261 | 4/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.50 |
| ▸ | APEX1 | P27695 | 2/20 | 0.50 |
| ▸ | CASP7 | P55210 | 2/20 | 0.50 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.50 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1675127 | 0.83 | CLK1 (1.00) | CLK1CLK4DYRK1ACLK2CLK3 | |
| SCHEMBL1675064 | 0.80 | CLK1 (0.67) | CLK1CLK4DYRK1ACLK2CLK3 | |
| SCHEMBL1675159 | 0.79 | CLK4 (1.00) | CLK1CLK4DYRK1ACLK2CLK3 | |
| SCHEMBL1675225 | 0.78 | CLK4 (0.69) | CLK1CLK4DYRK1ACLK2CLK3 | |
| SCHEMBL1675174 | 0.78 | CLK1 (1.00) | CLK1CLK4DYRK1ACLK2CLK3 | |
| SCHEMBL1675022 | 0.77 | CLK1 (0.64) | CLK1CLK4DYRK1ACLK2CLK3 | |
| SCHEMBL1675338 | 0.77 | CLK1 (0.66) | CLK1CLK4DYRK1ACLK2CLK3 | |
| SCHEMBL1675223 | 0.74 | CLK4 (0.73) | CLK1CLK4DYRK1ACLK2CLK3 | |
| SCHEMBL1675238 | 0.73 | CLK1 (0.58) | CLK1CLK4DYRK1ACLK2CLK3 | |
| SCHEMBL22726092 | 0.71 | CLK1 (0.56) | CLK1CLK4DYRK1ACLK2CLK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011041655-A1 | QUINAZOLIN-4-AMINE DERIVATIVES; AND METHODS OF USE | THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) | 2011-04-07 | — | — | WO | claimed |
| WO-2011041655-A1 | QUINAZOLIN-4-AMINE DERIVATIVES; AND METHODS OF USE | THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) | 2011-04-07 | — | — | WO | disclosed |