Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CLK4 | Q9HAZ1 | 14/20 | 0.66 |
| ▸ | CLK1 | P49759 | 6/20 | 0.66 |
| ▸ | CLK2 | P49760 | 6/20 | 0.66 |
| ▸ | DYRK1B | Q9Y463 | 6/20 | 0.66 |
| ▸ | DYRK1A | Q13627 | 6/20 | 0.66 |
| ▸ | CLK3 | P49761 | 1/20 | 0.52 |
| ▸ | CYP1A2 | P05177 | 6/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 6/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 6/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 4/20 | 0.43 |
| ▸ | USP2 | O75604 | 3/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | CD38 | P28907 | 1/20 | 0.43 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.43 |
| ▸ | ABL1 | P00519 | 1/20 | 0.43 |
| ▸ | EGFR | P00533 | 1/20 | 0.43 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.43 |
| ▸ | INSR | P06213 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1675210 | 0.88 | CLK4 (0.70) | CLK4CLK1CLK2DYRK1BDYRK1A | |
| SCHEMBL1675287 | 0.84 | CLK4 (0.79) | CLK4CLK1CLK2DYRK1BDYRK1A | |
| SCHEMBL1675128 | 0.82 | CLK4 (0.61) | CLK4CLK1CLK2DYRK1BDYRK1A | |
| SCHEMBL1675111 | 0.81 | CLK4 (0.57) | CLK4CLK1CLK2DYRK1BDYRK1A | |
| SCHEMBL1675219 | 0.81 | CLK4 (0.57) | CLK4CLK1CLK2DYRK1BDYRK1A | |
| SCHEMBL1675235 | 0.80 | CLK4 (0.75) | CLK4CLK1CLK2DYRK1BDYRK1A | |
| SCHEMBL1675356 | 0.80 | CLK4 (0.49) | CLK4CLK1CLK2DYRK1BDYRK1A | |
| SCHEMBL1675100 | 0.75 | CLK4 (0.55) | CLK4CLK1CLK2DYRK1BCYP1A2 | |
| SCHEMBL1675291 | 0.74 | CLK4 (0.50) | CLK4CLK1CLK2DYRK1BDYRK1A | |
| SCHEMBL1675131 | 0.71 | CLK4 (1.00) | CLK4CLK1CLK2DYRK1BDYRK1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011041655-A1 | QUINAZOLIN-4-AMINE DERIVATIVES; AND METHODS OF USE | THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) | 2011-04-07 | — | — | WO | claimed |
| WO-2011041655-A1 | QUINAZOLIN-4-AMINE DERIVATIVES; AND METHODS OF USE | THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) | 2011-04-07 | — | — | WO | disclosed |