SCHEMBL1675338

SCHEMBL1675338

Cc1occc1-c1ccc2ncnc(NCc3ncc[nH]3)c2c1

nearest known ligand 0.66

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CLK1 P49759 3/20 0.66
CLK4 Q9HAZ1 10/20 0.62
DYRK1A Q13627 5/20 0.62
CLK2 P49760 2/20 0.62
DYRK1B Q9Y463 2/20 0.62
CLK3 P49761 1/20 0.52
LMNA P02545 8/20 0.46
CYP3A4 P08684 6/20 0.46
TSHR P16473 6/20 0.46
CYP2D6 P10635 5/20 0.46
CYP2C19 P33261 5/20 0.46
ALDH1A1 P00352 5/20 0.46
CYP1A2 P05177 5/20 0.46
MAPK1 P28482 4/20 0.46
CYP2C9 P11712 4/20 0.46
ALOX15 P16050 1/20 0.46
APEX1 P27695 1/20 0.46
RECQL P46063 1/20 0.46
CASP7 P55210 1/20 0.46
HSD17B10 Q99714 4/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1675040 0.80 CLK4 (0.68) CLK1CLK4DYRK1ACLK2DYRK1B
SCHEMBL1675174 0.79 CLK1 (1.00) CLK1CLK4DYRK1ACLK2DYRK1B
SCHEMBL1675323 0.78 CLK4 (0.53) CLK1CLK4DYRK1ACLK2DYRK1B
SCHEMBL1675315 0.78 CLK4 (0.59) CLK1CLK4DYRK1ACLK2DYRK1B
SCHEMBL1675006 0.77 CLK1 (0.71) CLK1CLK4DYRK1ACLK2DYRK1B
SCHEMBL1675106 0.76 CLK4 (1.00) CLK1CLK4DYRK1ACLK2DYRK1B
SCHEMBL1675298 0.76 CLK4 (0.67) CLK1CLK4DYRK1ACLK2DYRK1B
SCHEMBL1675283 0.75 CLK4 (0.56) CLK1CLK4DYRK1ACLK2DYRK1B
SCHEMBL1675238 0.74 CLK1 (0.58) CLK1CLK4DYRK1ACLK2DYRK1B
SCHEMBL1675116 0.73 CLK4 (0.72) CLK1CLK4DYRK1ACLK2DYRK1B

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2011041655-A1 QUINAZOLIN-4-AMINE DERIVATIVES; AND METHODS OF USE THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) 2011-04-07 WO claimed
WO-2011041655-A1 QUINAZOLIN-4-AMINE DERIVATIVES; AND METHODS OF USE THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) 2011-04-07 WO disclosed