Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Arginine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRCP | P42785 | 2/20 | 0.38 |
| ▸ | OTC | P00480 | 1/20 | 0.36 |
| ▸ | NOS2 | P35228 | 3/20 | 0.35 |
| ▸ | NOS3 | P29474 | 2/20 | 0.35 |
| ▸ | NOS1 | P29475 | 2/20 | 0.35 |
| ▸ | DDAH1 | O94760 | 1/20 | 0.35 |
| ▸ | GSR | P00390 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.32 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Arginine SCHEMBL4807560 | 1.00 | PRCP (0.38) | PRCPOTCNOS2NOS3NOS1 | |
| Arginine SCHEMBL3087368 | 1.00 | PRCP (0.38) | PRCPOTCNOS2NOS3NOS1 | |
| Arginine SCHEMBL28774540 | 1.00 | PRCP (0.38) | PRCPOTCNOS2NOS3NOS1 | |
| Arginine SCHEMBL8697426 | 1.00 | PRCP (0.38) | PRCPOTCNOS2NOS3NOS1 | |
| Arginine SCHEMBL8582228 | 1.00 | PRCP (0.38) | PRCPOTCNOS2NOS3NOS1 | |
| Arginine SCHEMBL29164461 | 1.00 | PRCP (0.38) | PRCPOTCNOS2NOS3NOS1 | |
| Arginine SCHEMBL1417757 | 1.00 | PRCP (0.38) | PRCPOTCNOS2NOS3NOS1 | |
| Arginine SCHEMBL28470370 | 0.97 | PRCP (0.38) | PRCPOTCNOS2NOS3NOS1 | |
| Arginine SCHEMBL2123729 | 0.97 | PRCP (0.36) | PRCPOTCNOS2NOS3NOS1 | |
| Arginine SCHEMBL6534744 | 0.96 | PRCP (0.37) | PRCPOTCNOS2NOS3NOS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3149485-B1 | METHOD FOR DIAGNOSING A DISEASE OR A RISK TO DEVELOP A DISEASE TRANSMITTED VIA THE ALTERNATIVE PATHWAY OF THE COMPLEMENT SYSTEM | UNIV TUEBINGEN MEDIZINISCHE FAKULTAET (DE) | 2021-03-03 | — | — | EP | claimed |
| US-20170160291-A1 | METHOD FOR THE DIAGNOSIS OF OR RISK FOR A DISEASE MEDIATED VIA THE ALTERNATIVE PATHWAY OF THE COMPLEMENT SYSTEM | EBERHARD KARLS UNIVERSITAET TUEBINGEN MEDIZINISCHE FAKULTAET (DE) | 2017-06-08 | — | — | US | claimed |
| US-10416173-B2 | Method for the diagnosis of or risk for a disease mediated via the alternative pathway of the complement system | EBERHARD KARLS UNIVERSITAET TUEBINGEN MEDIZINISCHE FAKULTAET (DE) | 2019-09-17 | — | — | US | disclosed |
| US-20170160291-A1 | METHOD FOR THE DIAGNOSIS OF OR RISK FOR A DISEASE MEDIATED VIA THE ALTERNATIVE PATHWAY OF THE COMPLEMENT SYSTEM | EBERHARD KARLS UNIVERSITAET TUEBINGEN MEDIZINISCHE FAKULTAET (DE) | 2017-06-08 | — | — | US | disclosed |
| US-9458197-B2 | Elastin digest compositions and methods utilizing same | HUMAN MATRIX SCIENCES, LLC (US) | 2016-10-04 | — | — | US | disclosed |
| US-20150004184-A1 | ELASTIN DIGEST COMPOSITIONS AND METHODS UTILIZING SAME | NULASTIN, INC. | 2015-01-01 | — | — | US | disclosed |
| US-8871707-B2 | Elastin producing fibroblast formulations and methods of using the same | HUMAN MATRIX SCIENCES, LLC (US) | 2014-10-28 | — | — | US | disclosed |
| US-8828927-B2 | Elastin digest compositions and methods utilizing same | HUMAN MATRIX SCIENCES, LLC (US) | 2014-09-09 | — | — | US | disclosed |
| US-20130295122-A1 | ELASTIN DIGEST COMPOSITIONS AND METHODS UTILIZING SAME | NULASTIN, INC. | 2013-11-07 | — | — | US | disclosed |
| US-8461113-B2 | Elastin digest compositions and methods utilizing same | HUMAN MATRIX SCIENCES, LLC (US) | 2013-06-11 | — | — | US | disclosed |
| US-20110081322-A1 | ELASTIN PRODUCING FIBROBLAST FORMULATIONS AND METHODS OF USING THE SAME | NULASTIN, INC. | 2011-04-07 | — | — | US | disclosed |
| US-20090281044-A1 | ELASTIN DIGEST COMPOSITIONS AND METHODS UTILIZING SAME | NULASTIN, INC. | 2009-11-12 | — | — | US | disclosed |