Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Arginine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRCP | P42785 | 2/20 | 0.38 |
| ▸ | OTC | P00480 | 1/20 | 0.36 |
| ▸ | NOS2 | P35228 | 3/20 | 0.35 |
| ▸ | NOS3 | P29474 | 2/20 | 0.35 |
| ▸ | NOS1 | P29475 | 2/20 | 0.35 |
| ▸ | DDAH1 | O94760 | 1/20 | 0.35 |
| ▸ | GSR | P00390 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.32 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Arginine SCHEMBL8697426 | 1.00 | PRCP (0.38) | PRCPOTCNOS2NOS3NOS1 | |
| Arginine SCHEMBL1675364 | 1.00 | PRCP (0.38) | PRCPOTCNOS2NOS3NOS1 | |
| Arginine SCHEMBL28774540 | 1.00 | PRCP (0.38) | PRCPOTCNOS2NOS3NOS1 | |
| Arginine SCHEMBL4807560 | 1.00 | PRCP (0.38) | PRCPOTCNOS2NOS3NOS1 | |
| Arginine SCHEMBL3087368 | 1.00 | PRCP (0.38) | PRCPOTCNOS2NOS3NOS1 | |
| Arginine SCHEMBL1417757 | 1.00 | PRCP (0.38) | PRCPOTCNOS2NOS3NOS1 | |
| Arginine SCHEMBL29164461 | 1.00 | PRCP (0.38) | PRCPOTCNOS2NOS3NOS1 | |
| Arginine SCHEMBL2123729 | 0.97 | PRCP (0.36) | PRCPOTCNOS2NOS3NOS1 | |
| Arginine SCHEMBL28470370 | 0.97 | PRCP (0.38) | PRCPOTCNOS2NOS3NOS1 | |
| Arginine SCHEMBL6535144 | 0.96 | PRCP (0.37) | PRCPOTCNOS2NOS3NOS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0662093-A4 | HIV IMMUNOTHERAPEUTICS. | NISSIN FOOD PRODUCTS LTD (JP) | 1998-07-01 | — | — | EP | disclosed |
| US-5665569-A | POLYNUCLEOTIDE ENCODING A MONOCLONAL ANTIBODY | NISSIN SHOKUHIN KABUSHIKI KAISHA (JP) | 1997-09-09 | — | — | US | disclosed |
| US-5558865-A | NMO1 MONOCLONAL ANTIBODY | NISSIN SHOKUHIN KABUSHIKI KAISHA (JP) | 1996-09-24 | — | — | US | disclosed |
| EP-0662093-A1 | HIV IMMUNOTHERAPEUTICS | NISSIN SHOKUHIN KABUSHIKI KAISHA (JP) | 1995-07-12 | — | — | EP | disclosed |
| WO-1994004574-A1 | HIV IMMUNOTHERAPEUTICS | NISSIN SHOKUHIN KABUSHIKI KAISHA (JP) | 1994-03-03 | — | — | WO | disclosed |
| EP-0554446-A4 | — | — | 1994-02-09 | — | — | EP | disclosed |
| EP-0554446-A1 | Monoclonal antibodies useful in therapy of HIV-1 infection | NISSIN SHOKUHIN KABUSHIKI KAISHA (JP) | 1993-08-11 | — | — | EP | disclosed |
| WO-1993004090-A1 | HIV IMMUNOTHERAPEUTICS | NISSIN SHOKUHIN KABUSHIKI KAISHA (JP) | 1993-03-04 | — | — | WO | disclosed |
| WO-1992014489-A1 | POLIOVIRUS-BASED VACCINES | REPLIGEN CORPORATION (US) | 1992-09-03 | — | — | WO | disclosed |