Known targets — ChEMBL curated mechanism
ADORA1ADORA2AADORA2BADORA3PDE3APDE3BPDE4APDE4BPDE4CPDE4D
The experimentally established mechanism targets of Isoleucine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC7A5 | Q01650 | 1/20 | 0.46 |
| ▸ | GLRA1 | P23415 | 1/20 | 0.43 |
| ▸ | SLC6A9 | P48067 | 1/20 | 0.43 |
| ▸ | OR51E2 | Q9H255 | 1/20 | 0.43 |
| ▸ | DPP4 | P27487 | 11/20 | 0.43 |
| ▸ | DPP8 | Q6V1X1 | 7/20 | 0.43 |
| ▸ | DPP9 | Q86TI2 | 7/20 | 0.43 |
| ▸ | DPP7 | Q9UHL4 | 6/20 | 0.39 |
| ▸ | SLC1A3 | P43003 | 1/20 | 0.38 |
| ▸ | SLC1A2 | P43004 | 1/20 | 0.38 |
| ▸ | SLC1A1 | P43005 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Isoleucine SCHEMBL1537377 | 1.00 | SLC7A5 (0.46) | SLC7A5GLRA1SLC6A9OR51E2DPP4 | |
| Isoleucine SCHEMBL1537379 | 1.00 | SLC7A5 (0.46) | SLC7A5GLRA1SLC6A9OR51E2DPP4 | |
| Isoleucine SCHEMBL94554 | 1.00 | SLC7A5 (0.46) | SLC7A5GLRA1SLC6A9OR51E2DPP4 | |
| Isoleucine SCHEMBL4400069 | 1.00 | SLC7A5 (0.46) | SLC7A5GLRA1SLC6A9OR51E2DPP4 | |
| Isoleucine SCHEMBL8492488 | 1.00 | SLC7A5 (0.46) | SLC7A5GLRA1SLC6A9OR51E2DPP4 | |
| Isoleucine SCHEMBL3046356 | 1.00 | SLC7A5 (0.46) | SLC7A5GLRA1SLC6A9OR51E2DPP4 | |
| Isoleucine SCHEMBL1537299 | 1.00 | SLC7A5 (0.46) | SLC7A5GLRA1SLC6A9OR51E2DPP4 | |
| Isoleucine SCHEMBL11168084 | 0.96 | SLC7A5 (0.43) | SLC7A5GLRA1SLC6A9OR51E2DPP4 | |
| Isoleucine SCHEMBL3057441 | 0.96 | SLC7A5 (0.43) | SLC7A5GLRA1SLC6A9OR51E2DPP4 | |
| Isoleucine SCHEMBL2547350 | 0.96 | SLC7A5 (0.43) | SLC7A5GLRA1SLC6A9OR51E2DPP4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4340592-A | OLICOPEPTIDES FOR DIETARY PURPOSES | ADIBI SIAMAK A | 1982-07-20 | — | — | US | claimed |
| US-9458197-B2 | Elastin digest compositions and methods utilizing same | HUMAN MATRIX SCIENCES, LLC (US) | 2016-10-04 | — | — | US | disclosed |
| US-20150110755-A1 | ELASTIN PRODUCING FIBROBLAST FORMULATIONS AND METHODS OF USING THE SAME | NULASTIN, INC. | 2015-04-23 | — | — | US | disclosed |
| US-20150004184-A1 | ELASTIN DIGEST COMPOSITIONS AND METHODS UTILIZING SAME | NULASTIN, INC. | 2015-01-01 | — | — | US | disclosed |
| US-8871707-B2 | Elastin producing fibroblast formulations and methods of using the same | HUMAN MATRIX SCIENCES, LLC (US) | 2014-10-28 | — | — | US | disclosed |
| US-8828927-B2 | Elastin digest compositions and methods utilizing same | HUMAN MATRIX SCIENCES, LLC (US) | 2014-09-09 | — | — | US | disclosed |
| US-20130295122-A1 | ELASTIN DIGEST COMPOSITIONS AND METHODS UTILIZING SAME | NULASTIN, INC. | 2013-11-07 | — | — | US | disclosed |
| US-8461113-B2 | Elastin digest compositions and methods utilizing same | HUMAN MATRIX SCIENCES, LLC (US) | 2013-06-11 | — | — | US | disclosed |
| US-20110081322-A1 | ELASTIN PRODUCING FIBROBLAST FORMULATIONS AND METHODS OF USING THE SAME | NULASTIN, INC. | 2011-04-07 | — | — | US | disclosed |
| US-7666829-B2 | contains manganese chloride, manganese sulfate or manganese nitrate and ferric ammonium citrate or ferric chloride, for treating skin disorders; stimulating production of insoluble elastin, or deposition of collagen, fibroblasts; improve the appearance of scar; wrinkle resistance | HUMAN MATRIX SCIENCES, LLC (US) | 2010-02-23 | — | — | US | disclosed |
| US-20090281044-A1 | ELASTIN DIGEST COMPOSITIONS AND METHODS UTILIZING SAME | NULASTIN, INC. | 2009-11-12 | — | — | US | disclosed |
| EP-0173233-B1 | CHROMATOGRAPHIC METHOD AND MEANS | PURDUE RESEARCH FOUNDATION (US) | 1989-01-18 | — | — | EP | disclosed |
| EP-0173233-A2 | Chromatographic method and means | PURDUE RESEARCH FOUNDATION (US) | 1986-03-05 | — | — | EP | disclosed |
| US-4544485-A | HYDROPHOBIC COATING ON INNER SURFACES, HYDROPHILIC COATINGS ON OUTER SURFACES; SMALL PORE SIZE | PURDUE RESEARCH FOUNDATION (US) | 1985-10-01 | — | — | US | disclosed |