Known targets — ChEMBL curated mechanism
ADORA1ADORA2AADORA2BADORA3PDE3APDE3BPDE4APDE4BPDE4CPDE4D
The experimentally established mechanism targets of Isoleucine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC7A5 | Q01650 | 1/20 | 0.46 |
| ▸ | GLRA1 | P23415 | 1/20 | 0.43 |
| ▸ | SLC6A9 | P48067 | 1/20 | 0.43 |
| ▸ | OR51E2 | Q9H255 | 1/20 | 0.43 |
| ▸ | DPP4 | P27487 | 11/20 | 0.43 |
| ▸ | DPP8 | Q6V1X1 | 7/20 | 0.43 |
| ▸ | DPP9 | Q86TI2 | 7/20 | 0.43 |
| ▸ | DPP7 | Q9UHL4 | 6/20 | 0.39 |
| ▸ | SLC1A3 | P43003 | 1/20 | 0.38 |
| ▸ | SLC1A2 | P43004 | 1/20 | 0.38 |
| ▸ | SLC1A1 | P43005 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Isoleucine SCHEMBL1537377 | 1.00 | SLC7A5 (0.46) | SLC7A5GLRA1SLC6A9OR51E2DPP4 | |
| Isoleucine SCHEMBL1537379 | 1.00 | SLC7A5 (0.46) | SLC7A5GLRA1SLC6A9OR51E2DPP4 | |
| Isoleucine SCHEMBL94554 | 1.00 | SLC7A5 (0.46) | SLC7A5GLRA1SLC6A9OR51E2DPP4 | |
| Isoleucine SCHEMBL4400069 | 1.00 | SLC7A5 (0.46) | SLC7A5GLRA1SLC6A9OR51E2DPP4 | |
| Isoleucine SCHEMBL8492488 | 1.00 | SLC7A5 (0.46) | SLC7A5GLRA1SLC6A9OR51E2DPP4 | |
| Isoleucine SCHEMBL1537299 | 1.00 | SLC7A5 (0.46) | SLC7A5GLRA1SLC6A9OR51E2DPP4 | |
| Isoleucine SCHEMBL1675494 | 1.00 | SLC7A5 (0.46) | SLC7A5GLRA1SLC6A9OR51E2DPP4 | |
| Isoleucine SCHEMBL11168084 | 0.96 | SLC7A5 (0.43) | SLC7A5GLRA1SLC6A9OR51E2DPP4 | |
| Isoleucine SCHEMBL3057441 | 0.96 | SLC7A5 (0.43) | SLC7A5GLRA1SLC6A9OR51E2DPP4 | |
| Isoleucine SCHEMBL2547350 | 0.96 | SLC7A5 (0.43) | SLC7A5GLRA1SLC6A9OR51E2DPP4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 29 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1054677-B1 | COSMETIC OR DERMATOLOGICAL USE OF 7-HYDROXYLATED STEROIDS ALONE AND/OR IN COMBINATION WITH ELASTIN DERIVED PEPTIDES | CONNECTIVE TISSUE IMAGINEERING (US) | 2008-10-22 | — | — | EP | claimed |
| EP-1064010-A4 | PEPTIDE COMPOSITIONS AND FORMULATIONS AND USE OF SAME | CONNECTIVE TISSUE IMAGINEERING (US) | 2004-10-06 | — | — | EP | claimed |
| US-6777389-B1 | INHIBITING CUTANEOUS EFFECTS OF AGING | CONNECTIVE TISSUE IMAGINEERING LLC | 2004-08-17 | — | — | US | claimed |
| CN-1300220-A | Peptide compositions and formulations and use of same | MRS LTD (US) | 2001-06-20 | — | — | CN | claimed |
| EP-1064010-A1 | PEPTIDE COMPOSITIONS AND FORMULATIONS AND USE OF SAME | Mrs, Llc (US) | 2001-01-03 | — | — | EP | claimed |
| WO-1999045941-A1 | PEPTIDE COMPOSITIONS AND FORMULATIONS AND USE OF SAME | MRS, LLC (US) | 1999-09-16 | — | — | WO | claimed |
| US-7666842-B2 | Elastin peptide analogs and uses thereof | Connective Tissue Imagineering, LLC (US) | 2010-02-23 | — | — | US | disclosed |
| EP-1054677-B1 | COSMETIC OR DERMATOLOGICAL USE OF 7-HYDROXYLATED STEROIDS ALONE AND/OR IN COMBINATION WITH ELASTIN DERIVED PEPTIDES | CONNECTIVE TISSUE IMAGINEERING (US) | 2008-10-22 | — | — | EP | disclosed |
| EP-1064010-B1 | PEPTIDE COMPOSITIONS AND FORMULATIONS AND USE OF SAME | CONNECTIVE TISSUE IMAGINEERING (US) | 2008-02-20 | — | — | EP | disclosed |
| EP-1392346-A4 | COMPOSITION AND METHOD FOR ENHANCING ELASTICITY OF TISSUE | CONNECTIVE TISSUE IMAGINEERING (US) | 2006-10-25 | — | — | EP | disclosed |
| US-6962904-B1 | Elastin peptide analogs and uses thereof | CONNECTIVE TISSUE IMAGINEERING (US) | 2005-11-08 | — | — | US | disclosed |
| EP-1054677-A4 | COSMETIC OR DERMATOLOGICAL USE OF 7-HYDROXYLATED STEROIDS ALONE AND/OR IN COMBINATION WITH ELASTIN DERIVED PEPTIDES | MRS LLC (US) | 2005-07-27 | — | — | EP | disclosed |
| US-20050059599-A1 | Elastin peptide analogs and uses thereof | CONNECTIVE TISSUE IMAGINEERING LLC. | 2005-03-17 | — | — | US | disclosed |
| EP-1064010-A1 | PEPTIDE COMPOSITIONS AND FORMULATIONS AND USE OF SAME | Mrs, Llc (US) | 2001-01-03 | — | — | EP | disclosed |
| EP-1054677-A1 | COSMETIC OR DERMATOLOGICAL USE OF 7-HYDROXYLATED STEROIDS ALONE AND/OR IN COMBINATION WITH ELASTIN DERIVED PEPTIDES | Mrs, Llc (US) | 2000-11-29 | — | — | EP | disclosed |
| US-6069129-A | COMPOSITION FOR TREATING MAMMALIAN TISSUE COMPRISING PEPTIDE(S) OF GIVEN SEQUENCES; APPLYING TO HUMAN SKIN IN A COSMETIC OR THERAPEUTIC FORMULATION RESULTING IN ENHANCED ELASTICITY OF THE SKIN | MRS, LLC (US) | 2000-05-30 | — | — | US | disclosed |
| WO-2000028996-A1 | COSMETIC OR DERMATOLOGICAL USE OF 7-HYDROXYLATED STEROIDS ALONE AND/OR IN COMBINATION WITH ELASTIN DERIVED PEPTIDES | MRS, LLC (US) | 2000-05-25 | — | — | WO | disclosed |
| US-5977074-A | THERAPY FOR ALZHEIMER'S DISEASE | MERRELL PHARMACEUTICALS, INC. (US) | 1999-11-02 | — | — | US | disclosed |
| WO-1999045941-A1 | PEPTIDE COMPOSITIONS AND FORMULATIONS AND USE OF SAME | MRS, LLC (US) | 1999-09-16 | — | — | WO | disclosed |
| US-4382081-A | ANTIARRTHRITIC AGENTS | E. R. SQUIBB & SONS, INC. (US) | 1983-05-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050059599-A1 | Elastin peptide analogs and uses thereof | ELANE, CUTA, ENPEP | SLC7A5 2652/4885GLRA1 2283/4885SLC6A9 4693/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.