Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 4/20 | 0.62 |
| ▸ | MAP3K7 | O43318 | 3/20 | 0.51 |
| ▸ | IRAK4 | Q9NWZ3 | 3/20 | 0.51 |
| ▸ | IRAK1 | P51617 | 2/20 | 0.51 |
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | EPHB4 | P54760 | 2/20 | 0.45 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.43 |
| ▸ | LCK | P06239 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | TEC | P42680 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | BRAF | P15056 | 1/20 | 0.42 |
| ▸ | INSR | P06213 | 1/20 | 0.42 |
| ▸ | LYN | P07948 | 1/20 | 0.42 |
| ▸ | HCK | P08631 | 1/20 | 0.42 |
| ▸ | SRC | P12931 | 1/20 | 0.42 |
| ▸ | KDR | P35968 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16767967 | 0.90 | EGFR (0.61) | EGFRMAP3K7IRAK4IRAK1MAPT | |
| SCHEMBL16767958 | 0.88 | EGFR (0.61) | EGFRMAP3K7IRAK4IRAK1MAPT | |
| SCHEMBL16767966 | 0.86 | EGFR (0.60) | EGFRMAP3K7IRAK4IRAK1MAPT | |
| SCHEMBL16770023 | 0.86 | EGFR (0.58) | EGFRMAP3K7IRAK4IRAK1MAPT | |
| SCHEMBL16755394 | 0.80 | THRB (0.43) | MAPTALDH1A1RAB9AKMT2A | |
| SCHEMBL16767960 | 0.79 | EGFR (0.57) | EGFRRXFP1ALDH1A1TECMEN1 | |
| SCHEMBL20985290 | 0.78 | EGFR (0.67) | EGFRMAP3K7IRAK4IRAK1MAPT | |
| SCHEMBL13500556 | 0.77 | MAP3K7 (0.69) | EGFRMAP3K7IRAK4IRAK1EPHB4 | |
| SCHEMBL16755416 | 0.76 | EGFR (1.00) | EGFRMAP3K7IRAK4IRAK1TEC | |
| SCHEMBL20985384 | 0.76 | EGFR (0.66) | EGFRMAP3K7IRAK4IRAK1EPHB4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20150152083-A1 | Compounds and Compositions for Modulating EGFR Activity | IRM LLC, A DELAWARE LIMITED LIABILITY COMPANY (BM) | 2015-06-04 | — | — | US | disclosed |
| US-20150152083-A1 | Compounds and Compositions for Modulating EGFR Activity | IRM LLC, A DELAWARE LIMITED LIABILITY COMPANY (BM) | 2015-06-04 | — | — | US | disclosed |
| US-20150152083-A1 | Compounds and Compositions for Modulating EGFR Activity | IRM LLC, A DELAWARE LIMITED LIABILITY COMPANY (BM) | 2015-06-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150152083-A1 | Compounds and Compositions for Modulating EGFR Activity | EGFR, ERBB2, ERBB3 | EGFR 1/4885MAP3K7 183/4885IRAK4 1485/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.