SCHEMBL16758014

SCHEMBL16758014

CC1(C(N)=O)CCCN1C(=O)c1ccc(-c2cnc(OCC3CCN(CC4(C(F)(F)F)CCC4)CC3)cn2)cc1F

nearest known ligand 0.37

Predicted protein targets (top 10)

geneUniProtsupporting neighboursconfidence
GPR119 Q8TDV5 7/20 0.37
PIK3CA P42336 6/20 0.35
WNT1 P04628 2/20 0.35
GSK3B P49841 2/20 0.35
DYRK1A Q13627 2/20 0.35
DGAT1 O75907 1/20 0.35
CNR2 P34972 1/20 0.32
ALOX5AP P20292 2/20 0.32
FEN1 P39748 2/20 0.32
FFAR4 Q5NUL3 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL16758008 1.00 GPR119 (0.37) GPR119PIK3CAWNT1GSK3BDYRK1A
SCHEMBL16757777 0.94 GPR119 (0.37) GPR119PIK3CAWNT1GSK3BDYRK1A
SCHEMBL16757776 0.94 GPR119 (0.37) GPR119PIK3CAWNT1GSK3BDYRK1A
SCHEMBL16757930 0.94 GPR119 (0.37) GPR119WNT1GSK3BDYRK1ADGAT1
SCHEMBL16757934 0.94 GPR119 (0.37) GPR119WNT1GSK3BDYRK1ADGAT1
SCHEMBL16758114 0.92 GPR119 (0.36) GPR119PIK3CAWNT1GSK3BDYRK1A
SCHEMBL16758111 0.92 GPR119 (0.36) GPR119PIK3CAWNT1GSK3BDYRK1A
SCHEMBL18842756 0.92 GPR119 (0.39) GPR119PIK3CADGAT1CNR2ALOX5AP
SCHEMBL16757803 0.90 GPR119 (0.48) GPR119PIK3CAWNT1GSK3BDYRK1A
SCHEMBL16757807 0.90 GPR119 (0.48) GPR119PIK3CAWNT1GSK3BDYRK1A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3074384-A1 AMIDE DERIVATIVES FOR GPR119 AGONIST Chong Kun Dang Pharmaceutical Corp. (KR) 2016-10-05 EP claimed
WO-2015080446-A1 AMIDE DERIVATIVES FOR GPR119 AGONIST CHONG KUN DANG PHARMACEUTICAL CORP. (KR) 2015-06-04 WO claimed
EP-3074384-A1 AMIDE DERIVATIVES FOR GPR119 AGONIST Chong Kun Dang Pharmaceutical Corp. (KR) 2016-10-05 EP disclosed
WO-2015080446-A1 AMIDE DERIVATIVES FOR GPR119 AGONIST CHONG KUN DANG PHARMACEUTICAL CORP. (KR) 2015-06-04 WO disclosed