Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.48 |
| ▸ | F2 | P00734 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | CHRNA7 | P36544 | 2/20 | 0.46 |
| ▸ | CHRNB2 | P17787 | 2/20 | 0.41 |
| ▸ | CHRNA4 | P43681 | 2/20 | 0.41 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.41 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.41 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.40 |
| ▸ | HTR3B | O95264 | 1/20 | 0.40 |
| ▸ | HTR3A | P46098 | 1/20 | 0.40 |
| ▸ | HTR3D | Q70Z44 | 1/20 | 0.40 |
| ▸ | HTR3C | Q8WXA8 | 1/20 | 0.40 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.40 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.40 |
| ▸ | APOBEC3A | P31941 | 1/20 | 0.40 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.40 |
| ▸ | IKBKB | O14920 | 1/20 | 0.39 |
| ▸ | CHUK | O15111 | 1/20 | 0.39 |
| ▸ | HTR1A | P08908 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16759127 | 0.85 | CHRNA7 (0.55) | KMT2ACHRNA7CHRNB2CHRNA4CHRNB4 | |
| Hydrochloric Acid SCHEMBL6621806 | 0.84 | CHRNA7 (0.54) | KMT2ACHRNA7CHRNB2CHRNA4CHRNB4 | |
| SCHEMBL27867042 | 0.82 | LMNA (0.57) | KMT2AF2LMNACHRNA7HTR3E | |
| SCHEMBL27390676 | 0.81 | LMNA (0.55) | KMT2AF2LMNACHRNA7HTR3E | |
| SCHEMBL27771638 | 0.81 | CHRNA7 (0.54) | KMT2ALMNACHRNA7HTR3EHTR3B | |
| Benzamide SCHEMBL16758814 | 0.79 | KMT2A (0.40) | KMT2AHTR1ASLC6A2TSHRHSD17B10 | |
| SCHEMBL14256059 | 0.77 | SCN1A (0.56) | KMT2ACHRNA7CHRNB2CHRNA4CHRNB4 | |
| SCHEMBL16759167 | 0.77 | KMT2A (0.48) | KMT2AALDH1A1 | |
| SCHEMBL16759023 | 0.76 | KMT2A (0.58) | KMT2AF2LMNACHRNA7CHRNB2 | |
| SCHEMBL14390376 | 0.75 | CHRNA7 (0.58) | KMT2ACHRNA7HTR3EHTR3BHTR3A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3074377-A1 | SUBSTITUTED BENZAMIDES AND METHODS OF USE THEREOF | Genentech, Inc. (US) | 2016-10-05 | — | — | EP | disclosed |
| WO-2015078374-A1 | SUBSTITUTED BENZAMIDES AND METHODS OF USE THEREOF | GENENTECH, INC. (US) | 2015-06-04 | — | — | WO | disclosed |