Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.46 |
| ▸ | LTA4H | P09960 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.44 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | DPP4 | P27487 | 1/20 | 0.43 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.42 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.42 |
| ▸ | HRH1 | P35367 | 1/20 | 0.41 |
| ▸ | CTNNB1 | P35222 | 1/20 | 0.41 |
| ▸ | BRD4 | O60885 | 2/20 | 0.41 |
| ▸ | SLC6A2 | P23975 | 3/20 | 0.40 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.40 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL491473 | 0.86 | CA1 (0.39) | TSHRALDH1A1MAPK1HTTL3MBTL1 | |
| SCHEMBL9217031 | 0.83 | NCOA1 (0.55) | TSHRLTA4HALDH1A1MAPK1HTT | |
| SCHEMBL18189714 | 0.83 | GAPDH (0.45) | TSHRLTA4HALDH1A1MAPK1L3MBTL1 | |
| Ethane SCHEMBL29030193 | 0.82 | CA1 (0.42) | TSHRALDH1A1MAPK1HTTL3MBTL1 | |
| SCHEMBL6406032 | 0.81 | NCOA1 (0.55) | TSHRLTA4HALDH1A1MAPK1HTT | |
| Formaldehyde SCHEMBL28708546 | 0.80 | TOP1 (0.38) | ALDH1A1MAPK1HTTL3MBTL1LMNA | |
| SCHEMBL497256 | 0.79 | NCOA1 (0.55) | TSHRLTA4HALDH1A1MAPK1NCOA1 | |
| SCHEMBL10927218 | 0.79 | ADORA2A (0.60) | ALDH1A1MAPK1HTTL3MBTL1LMNA | |
| SCHEMBL7544988 | 0.79 | BRD4 (0.43) | ALDH1A1NCOA1NCOA3GAAKMT2A | |
| SCHEMBL2203391 | 0.79 | TSHR (0.58) | TSHRLTA4HALDH1A1MAPK1HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-2007523903-A | — | — | 2007-08-23 | — | — | JP | claimed |
| EP-1730118-A1 | SUBSTITUTED AZOLE DERIVATIVES, COMPOSITIONS, AND METHODS OF USE | Transtech Pharma, Inc. (US) | 2006-12-13 | — | — | EP | claimed |
| WO-2005080346-A1 | SUBSTITUTED AZOLE DERIVATIVES, COMPOSITIONS, AND METHODS OF USE | TRANSTECH PHARMA, INC. (US) | 2005-09-01 | — | — | WO | claimed |
| US-20050187277-A1 | Substituted azole derivatives, compositions, and methods of use | TRANSTECH PHARMA, INC. | 2005-08-25 | — | — | US | claimed |
| EP-0197417-B1 | HEAT EXCHANGE LIQUIDS | BAYER AG (DE) | 1988-09-14 | — | — | EP | claimed |
| EP-0197417-A1 | Heat exchange liquids | BAYER AG (DE) | 1986-10-15 | — | — | EP | claimed |
| US-20110092553-A1 | Substituted Azole Derivatives, Compositions, and Methods of Use | TRANSTECH PHARMA, INC. (US) | 2011-04-21 | — | — | US | disclosed |
| EP-1730118-A1 | SUBSTITUTED AZOLE DERIVATIVES, COMPOSITIONS, AND METHODS OF USE | Transtech Pharma, Inc. (US) | 2006-12-13 | — | — | EP | disclosed |
| WO-2005080346-A1 | SUBSTITUTED AZOLE DERIVATIVES, COMPOSITIONS, AND METHODS OF USE | TRANSTECH PHARMA, INC. (US) | 2005-09-01 | — | — | WO | disclosed |
| US-20050187277-A1 | Substituted azole derivatives, compositions, and methods of use | TRANSTECH PHARMA, INC. | 2005-08-25 | — | — | US | disclosed |
| US-5338887-A | Process for the preparation of dihydroperoxyalkyl polyphenyls and dihydroxy polyphenyls | THE DOW CHEMICAL COMPANY (US) | 1994-08-16 | — | — | US | disclosed |
| EP-0197417-B1 | HEAT EXCHANGE LIQUIDS | BAYER AG (DE) | 1988-09-14 | — | — | EP | disclosed |
| EP-0197417-A1 | Heat exchange liquids | BAYER AG (DE) | 1986-10-15 | — | — | EP | disclosed |
| EP-0197417-A1 | Heat exchange liquids | BAYER AG (DE) | 1986-10-15 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110092553-A1 | Substituted Azole Derivatives, Compositions, and Methods of Use | PTPRO, PTPN5, PTPRE | TSHR 3409/4885LTA4H 1580/4885ALDH1A1 747/4885 |
| US-20050187277-A1 | Substituted azole derivatives, compositions, and methods of use | PTPRO, PTPN5, PTPRE | TSHR 3409/4885LTA4H 1580/4885ALDH1A1 747/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.