Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RET | P07949 | 17/20 | 0.79 |
| ▸ | KDR | P35968 | 16/20 | 0.79 |
| ▸ | KIF5B | P33176 | 13/20 | 0.79 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.63 |
| ▸ | FLT1 | P17948 | 2/20 | 0.63 |
| ▸ | GAK | O14976 | 1/20 | 0.60 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.60 |
| ▸ | STK10 | O94804 | 1/20 | 0.60 |
| ▸ | EGFR | P00533 | 1/20 | 0.60 |
| ▸ | FLT3 | P36888 | 1/20 | 0.60 |
| ▸ | JAK3 | P52333 | 1/20 | 0.60 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.60 |
| ▸ | Q6ZSR9 | Q6ZSR9 | 1/20 | 0.60 |
| ▸ | SLK | Q9H2G2 | 1/20 | 0.60 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.60 |
| ▸ | RPS6KA6 | Q9UK32 | 1/20 | 0.60 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.60 |
| ▸ | SRC | P12931 | 1/20 | 0.60 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16760379 | 0.88 | RET (1.00) | RETKDRKIF5BFGFR1FLT1 | |
| Hydrochloric Acid SCHEMBL16760482 | 0.87 | RET (0.98) | RETKDRKIF5BFGFR1FLT1 | |
| SCHEMBL18158909 | 0.84 | RET (1.00) | RETKDRKIF5BFGFR1FLT1 | |
| SCHEMBL18153625 | 0.84 | RET (0.82) | RETKDRKIF5BFGFR1FLT1 | |
| Hydrochloric Acid SCHEMBL18153626 | 0.83 | KDR (0.80) | RETKDRKIF5BFGFR1FLT1 | |
| SCHEMBL16785515 | 0.83 | RET (1.00) | RETKDRKIF5BFGFR1FLT1 | |
| Hydrochloric Acid SCHEMBL16760376 | 0.82 | RET (0.98) | RETKDRKIF5BFGFR1FLT1 | |
| SCHEMBL6288560 | 0.81 | KDR (0.77) | RETKDRKIF5BFGFR1FLT1 | |
| SCHEMBL5865163 | 0.81 | KDR (0.70) | RETKDRKIF5BFGFR1FLT1 | |
| SCHEMBL16760487 | 0.81 | RET (0.80) | RETKDRKIF5B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2015079251-A1 | QUINAZOLINE COMPOUNDS | CANCER RESEARCH TECHNOLOGY LIMITED (GB) | 2015-06-04 | — | — | WO | claimed |
| WO-2015079251-A1 | QUINAZOLINE COMPOUNDS | CANCER RESEARCH TECHNOLOGY LIMITED (GB) | 2015-06-04 | — | — | WO | disclosed |