Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 16/20 | 0.77 |
| ▸ | RET | P07949 | 17/20 | 0.73 |
| ▸ | KIF5B | P33176 | 14/20 | 0.69 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.64 |
| ▸ | FLT1 | P17948 | 1/20 | 0.64 |
| ▸ | EGFR | P00533 | 2/20 | 0.62 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5864787 | 0.89 | RET (0.76) | KDRRETKIF5BFGFR1FLT1 | |
| SCHEMBL27109251 | 0.87 | KDR (1.00) | KDRRETKIF5BFGFR1FLT1 | |
| SCHEMBL7866068 | 0.85 | KDR (0.80) | KDRRETKIF5BFGFR1FLT1 | |
| SCHEMBL7076160 | 0.85 | RET (1.00) | KDRRETKIF5BFLT1EGFR | |
| SCHEMBL5564490 | 0.84 | HTT (0.61) | KDRRETEGFR | |
| Hydrochloric Acid SCHEMBL7870586 | 0.84 | KDR (0.78) | KDRRETKIF5BFGFR1FLT1 | |
| SCHEMBL2055589 | 0.83 | RAF1 (0.76) | KDRRETKIF5BFGFR1FLT1 | |
| SCHEMBL18153625 | 0.82 | RET (0.82) | KDRRETKIF5BFGFR1FLT1 | |
| Hydrochloric Acid SCHEMBL18153626 | 0.81 | KDR (0.80) | KDRRETKIF5BFGFR1FLT1 | |
| SCHEMBL16785515 | 0.81 | RET (1.00) | KDRRETKIF5BFGFR1FLT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005115145-A2 | QUINONE SUBSTITUTED QUINAZOLINE AND QUINOLINE KINASE INHIBITORS | WYETH (US) | 2005-12-08 | — | — | WO | disclosed |