Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 5/20 | 0.67 |
| ▸ | EPHA2 | P29317 | 3/20 | 0.67 |
| ▸ | EPHB4 | P54760 | 2/20 | 0.67 |
| ▸ | FLT1 | P17948 | 2/20 | 0.67 |
| ▸ | ENPP1 | P22413 | 3/20 | 0.61 |
| ▸ | RET | P07949 | 1/20 | 0.56 |
| ▸ | KIF5B | P33176 | 1/20 | 0.56 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.51 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.49 |
| ▸ | PDGFRB | P09619 | 3/20 | 0.48 |
| ▸ | PDGFRA | P16234 | 3/20 | 0.48 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.48 |
| ▸ | HTT | P42858 | 2/20 | 0.47 |
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
| ▸ | RAF1 | P04049 | 1/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | ATM | Q13315 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | EGFR | P00533 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29631520 | 0.86 | ENPP1 (0.68) | KDRENPP1RETHTTLMNA | |
| SCHEMBL297514 | 0.86 | ENPP1 (0.68) | KDRENPP1RETHTTLMNA | |
| SCHEMBL295891 | 0.86 | ENPP1 (0.68) | KDRENPP1RETHTTLMNA | |
| Hydrochloric Acid SCHEMBL156332 | 0.85 | ENPP1 (0.67) | ENPP1PDGFRBPDGFRAHTTLMNA | |
| Hydrochloric Acid SCHEMBL28041015 | 0.85 | ENPP1 (0.67) | ENPP1PDGFRBPDGFRAHTTLMNA | |
| Hydrochloric Acid SCHEMBL28102763 | 0.85 | ENPP1 (0.67) | ENPP1PDGFRBPDGFRAHTTLMNA | |
| SCHEMBL7205078 | 0.85 | ENPP1 (0.67) | KDREPHA2EPHB4FLT1ENPP1 | |
| SCHEMBL906880 | 0.81 | EPHA2 (1.00) | KDREPHA2EPHB4FLT1ERBB2 | |
| SCHEMBL8857758 | 0.79 | ENPP1 (0.56) | ENPP1HTTLMNAMAPK1ATM | |
| SCHEMBL364049 | 0.79 | ENPP1 (0.81) | KDRFLT1ENPP1RETLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2015079251-A1 | QUINAZOLINE COMPOUNDS | CANCER RESEARCH TECHNOLOGY LIMITED (GB) | 2015-06-04 | — | — | WO | disclosed |
| WO-2015079251-A1 | QUINAZOLINE COMPOUNDS | CANCER RESEARCH TECHNOLOGY LIMITED (GB) | 2015-06-04 | — | — | WO | disclosed |