Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ENPP1 | P22413 | 3/20 | 0.81 |
| ▸ | KDR | P35968 | 2/20 | 0.55 |
| ▸ | FLT1 | P17948 | 1/20 | 0.55 |
| ▸ | EGFR | P00533 | 9/20 | 0.54 |
| ▸ | SRC | P12931 | 4/20 | 0.54 |
| ▸ | CSF1R | P07333 | 2/20 | 0.54 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.54 |
| ▸ | NOD1 | Q9Y239 | 1/20 | 0.54 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.54 |
| ▸ | AURKA | O14965 | 1/20 | 0.53 |
| ▸ | LCK | P06239 | 3/20 | 0.52 |
| ▸ | MEN1 | O00255 | 2/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.51 |
| ▸ | MAPT | P10636 | 2/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.51 |
| ▸ | GMNN | O75496 | 1/20 | 0.51 |
| ▸ | ABL1 | P00519 | 1/20 | 0.51 |
| ▸ | LMNA | P02545 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29359187 | 1.00 | ENPP1 (0.81) | ENPP1KDRFLT1EGFRSRC | |
| Hydrochloric Acid SCHEMBL3526531 | 0.98 | ENPP1 (0.79) | ENPP1KDRFLT1EGFRSRC | |
| SCHEMBL30591048 | 0.90 | ENPP1 (1.00) | ENPP1KDRFLT1EGFRSRC | |
| SCHEMBL22441608 | 0.90 | ENPP1 (0.78) | ENPP1KDRFLT1EGFRSRC | |
| SCHEMBL31457605 | 0.90 | ENPP1 (0.78) | ENPP1KDRFLT1EGFRSRC | |
| SCHEMBL1012109 | 0.90 | ENPP1 (1.00) | ENPP1KDRFLT1EGFRSRC | |
| SCHEMBL1013282 | 0.90 | ENPP1 (1.00) | ENPP1KDRFLT1EGFRSRC | |
| SCHEMBL7807551 | 0.89 | ENPP1 (0.67) | ENPP1KDRFLT1EGFRSRC | |
| SCHEMBL856586 | 0.89 | ENPP1 (0.67) | ENPP1KDRFLT1EGFRSRC | |
| SCHEMBL22441451 | 0.89 | ENPP1 (0.76) | ENPP1KDRFLT1EGFRSRC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1048 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114105890-A | 3-cyanophenyl-6, 7-dimethoxy-quinazoline and preparation method and application thereof | 安徽益多康尔医药科技有限公司 | 2022-03-01 | — | — | CN | claimed |
| CN-109553612-B | Pyrazolopyrimidine derivative, preparation method thereof and application thereof in medicine preparation | 广西梧州制药（集团）股份有限公司 | 2021-09-03 | — | — | CN | claimed |
| CN-113264889-A | Method suitable for industrial production and preparation of gefitinib | 广西师范大学 | 2021-08-17 | — | — | CN | claimed |
| CN-110894189-A | Preparation method of erlotinib hydrochloride | 山东罗欣药业集团股份有限公司 | 2020-03-20 | — | — | CN | claimed |
| US-20170298029-A1 | RAF KINASE MODULATOR COMPOUNDS AND METHODS OF USE THEREOF | AMBIT BIOSCIENCES CORPORATION (US) | 2017-10-19 | — | — | US | claimed |
| CN-106946857-A | 3-triazole compounds of Tarceva 1,2,3 with antitumor activity and its preparation method and application | 河南师范大学 | 2017-07-14 | — | — | CN | claimed |
| CN-104892530-A | Diaryl urea compound containing quinazoline structure as well as preparation method and application thereof | UNIV YANTAI | 2015-09-09 | — | — | CN | claimed |
| CN-104892529-A | Thiourea compound containing quinazoline structure as well as preparation method and application of thiourea compound | UNIV YANTAI | 2015-09-09 | — | — | CN | claimed |
| CN-101735157-B | Preparation method of erlotinib hydrochloride | SHANGHAI NORTHCAROLINA CHEMLABS CO LTD | 2012-08-22 | — | — | CN | claimed |
| CN-101735157-A | Preparation method of erlotinib hydrochloride | SHANGHAI NORTHCAROLINA CHEMLAB | 2010-06-16 | — | — | CN | claimed |
| EP-3941459-B1 | QUINOLINE AND QUINAZOLINE COMPOUNDS AND METHODS OF USE THEREOF | STINGRAY THERAPEUTICS INC (US) | 2026-05-06 | — | — | EP | disclosed |
| EP-4100394-B1 | INHIBITORS OF ECTONUCLEOTIDE PYROPHOSPHATASE/PHOSPHODIESTERASE 1 (ENPP1) AND METHODS OF USE THEREOF | STINGRAY THERAPEUTICS INC (US) | 2026-04-08 | — | — | EP | disclosed |
| US-20260022135-A1 | ECTONUCLEOTIDE PYROPHOSPHATASE-PHOSPHODIESTERASE-1 (ENPP1) INHIBITORS AND USES THEREOF | 1CBIO INC (US) | 2026-01-22 | — | — | US | disclosed |
| US-12497394-B2 | Fused-cyclic pyrazolone formamide compound and preparation method therefor, pharmaceutical composition and use thereof | SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES (CN) | 2025-12-16 | — | — | US | disclosed |
| US-12371428-B2 | Pyridone compounds and methods of use | EXELIXIS, INC. (US) | 2025-07-29 | — | — | US | disclosed |
| EP-0094766-A2 | Quinazoline cardiac stimulants | Pfizer Limited (GB) | 1983-11-23 | — | — | EP | disclosed |
| US-4188391-A | 4-[4-(Substituted)piperidino]quinazoline cardiac stimulants | PFIZER INC. (US) | 1980-02-12 | — | — | US | disclosed |
| US-4011323-A | ANTIOBESITY AND ANTIDIABETIC | SANDOZ, INC. (US) | 1977-03-08 | — | — | US | disclosed |
| US-3966936-A | MUSCLE RELAXANTS | PFIZER INC. (US) | 1976-06-29 | — | — | US | disclosed |
| US-3954987-A | 2-Alkyl-4-substituted amino-quinazolines and nitrates thereof in the treatment of myocardial shock | SANDOZ, INC. (US) | 1976-05-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170298029-A1 | RAF KINASE MODULATOR COMPOUNDS AND METHODS OF USE THEREOF | BRAF, RAF1, ARAF | ENPP1 1136/4885KDR 982/4885FLT1 1253/4885 |
| US-12371428-B2 | Pyridone compounds and methods of use | PDXK, PLK2, MAP4K2 | ENPP1 366/4885KDR 2892/4885FLT1 3640/4885 |
| US-20260022135-A1 | ECTONUCLEOTIDE PYROPHOSPHATASE-PHOSPHODIESTERASE-1 (ENPP1) INHIBITORS AND USES THEREOF | ENPP1, ENPP3, NCEH1 | ENPP1 1/4885KDR 2641/4885FLT1 3810/4885 |
| US-12497394-B2 | Fused-cyclic pyrazolone formamide compound and preparation method therefor, pharmaceutical composition and use thereof | AXL, WEE1, FLT3 | ENPP1 1206/4885KDR 73/4885FLT1 6/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.