Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KIF18A | Q8NI77 | 15/20 | 0.54 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.42 |
| ▸ | BTK | Q06187 | 2/20 | 0.39 |
| ▸ | JAK3 | P52333 | 1/20 | 0.39 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16766237 | 1.00 | KIF18A (0.54) | KIF18AMAP4K4BTKJAK3PDE10A | |
| SCHEMBL16790987 | 0.84 | KIF18A (0.53) | KIF18AMAP4K4BTKJAK3PDE10A | |
| Hydrochloric Acid SCHEMBL16765843 | 0.83 | KIF18A (0.53) | KIF18AMAP4K4BTKJAK3PDE10A | |
| SCHEMBL16765875 | 0.83 | KIF18A (0.62) | KIF18AMAP4K4BTKJAK3PDE10A | |
| SCHEMBL16765873 | 0.83 | KIF18A (0.62) | KIF18AMAP4K4BTKJAK3PDE10A | |
| Hydrochloric Acid SCHEMBL16765842 | 0.83 | KIF18A (0.53) | KIF18AMAP4K4BTKJAK3PDE10A | |
| SCHEMBL16765712 | 0.78 | KIF18A (0.54) | KIF18AMAP4K4BTKJAK3PDE10A | |
| SCHEMBL16765711 | 0.78 | KIF18A (0.54) | KIF18AMAP4K4BTKJAK3PDE10A | |
| SCHEMBL13488656 | 0.75 | CDK5 (0.52) | KIF18A | |
| SCHEMBL18427265 | 0.75 | GSK3B (0.41) | KIF18AMAP4K4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3077384-B1 | HETEROARYL PYRIDONE AND AZA-PYRIDONE COMPOUNDS WITH ELECTROPHILIC FUNCTIONALITY | HOFFMANN LA ROCHE (CH) | 2017-09-06 | — | — | EP | disclosed |
| EP-3077384-A1 | HETEROARYL PYRIDONE AND AZA-PYRIDONE COMPOUNDS WITH ELECTROPHILIC FUNCTIONALITY | F. Hoffmann-La Roche AG (CH) | 2016-10-12 | — | — | EP | disclosed |
| US-9260415-B2 | Heteroaryl pyridone and aza-pyridone compounds with electrophilic functionality | GENENTECH, INC. (US) | 2016-02-16 | — | — | US | disclosed |
| US-20150158846-A1 | HETEROARYL PYRIDONE AND AZA-PYRIDONE COMPOUNDS WITH ELECTROPHILIC FUNCTIONALITY | GENENTECH, INC. (US) | 2015-06-11 | — | — | US | disclosed |
| WO-2015082583-A1 | HETEROARYL PYRIDONE AND AZA-PYRIDONE COMPOUNDS WITH ELECTROPHILIC FUNCTIONALITY | F. HOFFMANN-LA ROCHE AG (CH) | 2015-06-11 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150158846-A1 | HETEROARYL PYRIDONE AND AZA-PYRIDONE COMPOUNDS WITH ELECTROPHILIC FUNCTIONALITY | BTK, TYK2, LCK | KIF18A 3923/4885MAP4K4 175/4885BTK 1/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.