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Sugi Predict / Targets / KIF18A

KIF18A

Kinesin-like protein KIF18A · Q8NI77 · KIF18A on Sugi Atlas →

17,075 patent compounds predicted against KIF18A, 7,843 high-confidence (nearest known ligand ≥ 0.5)

Top predicted compounds (top 20 by supporting neighbours, then confidence)

CompoundConfidenceSupporting neighbours
SCHEMBL397299 SCHEMBL397299 0.46 17/20
SCHEMBL5045480 SCHEMBL5045480 0.51 16/20
SCHEMBL5044973 SCHEMBL5044973 0.50 16/20
SCHEMBL3037467 SCHEMBL3037467 0.43 16/20
SCHEMBL6831083 SCHEMBL6831083 0.42 16/20
SCHEMBL6826008 SCHEMBL6826008 0.57 13/20
SCHEMBL5041480 SCHEMBL5041480 0.50 13/20
SCHEMBL5048260 SCHEMBL5048260 0.51 12/20
SCHEMBL3199360 SCHEMBL3199360 0.49 12/20
SCHEMBL3219593 SCHEMBL3219593 0.46 11/20
SCHEMBL6825984 SCHEMBL6825984 0.60 9/20
SCHEMBL6829454 SCHEMBL6829454 0.52 9/20
SCHEMBL1000620 SCHEMBL1000620 0.48 9/20
SCHEMBL3214389 SCHEMBL3214389 0.48 9/20
SCHEMBL6829260 SCHEMBL6829260 0.46 9/20
SCHEMBL1075398 SCHEMBL1075398 0.46 9/20
SCHEMBL6647795 SCHEMBL6647795 0.46 9/20
SCHEMBL6830890 SCHEMBL6830890 0.41 9/20
SCHEMBL6646498 SCHEMBL6646498 0.50 8/20
SCHEMBL6645751 SCHEMBL6645751 0.47 8/20

Clinical trials — most relevant to KIF18A by text similarity (a relevance ranking, not an exhaustive list)

TrialPhaseStatus
AK112 or Placebo Plus Nab-Paclitaxel as First-line Treatment in Inoperable Locally Advanced/ Metastatic Triple-negative Breast Cancer PHASE3RECRUITING
A Study to Investigate Safety, Tolerability, Pharmacokinetics and Preliminary Efficacy With GenSci122 in Participants With Advanced Solid Tumors PHASE1RECRUITING
Genetic Study of Patients With Primary Ciliary Dyskinesia nanCOMPLETED
Natural History Study of SLC25A46 Mutation-related Mitochondriopathy nanCOMPLETED
Biomarker Research in Inherited Movement Disorders nanRECRUITING
Registry and Natural History of Epilepsy-Dyskinesia Syndromes nanRECRUITING
Chromosome 18 Clinical Research Center nanRECRUITING
Progressive Familial Intrahepatic Cholestasis in Indian Children - Establishing an Indian PFIC Registry nanUNKNOWN
Gait in Rare Diseases nanCOMPLETED
Classification, Functional Stratification and Biomarkers in Ciliopathy (CILLICORIRCM) nanCOMPLETED
Integrated Model for Promoting Parenting and Early School Readiness in Pediatrics nanCOMPLETED
Delineating the Molecular Spectrum and the Clinical, Imaging and Neuronal Phenotype of Chopra-Amiel-Gordon Syndrome nanRECRUITING
Genetic Studies of Strabismus, Congenital Cranial Dysinnervation Disorders (CCDDs), and Their Associated Anomalies nanRECRUITING
Natural History Evaluation of Charcot Marie Tooth Disease (CMT) Types CMT1B, CMT2A, CMT4A, CMT4C, and Others nanRECRUITING
Mapping Disease Pathways for Biliary Atresia nanRECRUITING
Hong Kong Spinocerebellar Ataxias Registry nanRECRUITING
Core Stability Exercises and Hereditary Ataxia nanCOMPLETED
Evaluation and Treatment of Pediatric, Developmental, and Genetic Eye Diseases nanCOMPLETED
Better Delineation of CDK13 Related Phenotype and Epigenetic Signature. nanUNKNOWN
iPSC Neurons From Adult Survivors of Childhood Cancer Who Have Persistent Vincristine-Induced Neuropathy nanCOMPLETED
Exploring a Motor Learning Technique Based on the Mirror Motor Neuron System nanCOMPLETED
Assessing the Polygenic Burden of Rare Disruptive Mutations in Parkinson's Disease nanUNKNOWN
Natural History, Pathogenesis and Outcome of Melorheostosis A Rare Osteosclerotic Disease nanRECRUITING
A Retrospective Survey-based Multicenter Study to Delineate the Molecular and Phenotypic Spectrum of Epilepsy-dyskinesia Syndromes nanRECRUITING
Investigating Phenotypic, Epigenetic, and NeuroGenetic Traits in Rare and Ultra-rare Neurodevelopmental Disorders (Project PENGUIN) nanRECRUITING
Muscle Tissue Bank for Muscular Dystrophy nanCOMPLETED
Genetics of Pediatric-Onset Motor Neuron and Neuromuscular Diseases nanCOMPLETED
Result Of Karyotyping in Pediatric Patients With Congenital Anomalies and Developmental Delay nanNOT_YET_RECRUITING
Clinical Registry Investigating Bardet-Biedl Syndrome nanRECRUITING
Pathogenesis of Primary Ciliary Dyskinesia (PCD) Lung Disease nanRECRUITING

Related proteins — ESM-2 sequence neighbours (a KIF18A binder may also engage these)

ProteinNameSimilarity
Q91WD7 — 1.000 Q91WD7 →
Q86VH2 — 0.999 Q86VH2 →
Q80WE4 — 0.997 Q80WE4 →
F4JZ68 — 0.997 F4JZ68 →
Q80TF6 — 0.996 Q80TF6 →
Q2VIQ3 — 0.995 Q2VIQ3 →
Q8GS71 — 0.995 Q8GS71 →
P46863 — 0.995 P46863 →
Q15058 — 0.995 Q15058 →
Q8LNZ2 — 0.994 Q8LNZ2 →
Q8S949 — 0.994 Q8S949 →
Q8L7Y8 — 0.994 Q8L7Y8 →
Q651Z7 — 0.993 Q651Z7 →
B3H6Z8 — 0.993 B3H6Z8 →
Q5ZLK6 — 0.993 Q5ZLK6 →
L0N7N1 — 0.993 L0N7N1 →
Q6PFD6 — 0.993 Q6PFD6 →
Q9AWM8 — 0.993 Q9AWM8 →
Q90640 — 0.993 Q90640 →
Q6Z9D2 — 0.992 Q6Z9D2 →
O95625 — 0.992 O95625 →
O59751 — 0.992 O59751 →
A2ZRG4 — 0.992 A2ZRG4 →
F4I1T9 — 0.992 F4I1T9 →
Q91785 — 0.992 Q91785 →
F4JQ51 — 0.992 F4JQ51 →
F4JX00 — 0.992 F4JX00 →
Q8BMD7 — 0.992 Q8BMD7 →
Q7ZXX2 — 0.992 Q7ZXX2 →
F4IJK6 — 0.992 F4IJK6 →