Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BCHE | P06276 | 1/20 | 0.38 |
| ▸ | ACHE | P22303 | 1/20 | 0.38 |
| ▸ | BACE1 | P56817 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 3/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | HTT | P42858 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.37 |
| ▸ | CXCR3 | P49682 | 1/20 | 0.36 |
| ▸ | TACR1 | P25103 | 3/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | CARM1 | Q86X55 | 1/20 | 0.33 |
| ▸ | PRMT6 | Q96LA8 | 1/20 | 0.33 |
| ▸ | NSD2 | O96028 | 1/20 | 0.33 |
| ▸ | DPP4 | P27487 | 1/20 | 0.33 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.33 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16767684 | 0.85 | KDM4E (0.38) | KDM4EHTTMEN1KMT2AGAA | |
| SCHEMBL16767692 | 0.82 | BACE1 (0.40) | BCHEACHEBACE1POLBHTT | |
| SCHEMBL28081424 | 0.81 | KDM1A (0.39) | BACE1KDM4EHTTMEN1KMT2A | |
| SCHEMBL16767640 | 0.80 | MEN1 (0.41) | BCHEACHEBACE1POLBMEN1 | |
| SCHEMBL16767574 | 0.80 | BACE1 (0.39) | BCHEACHEBACE1POLBHTT | |
| SCHEMBL16767615 | 0.78 | BACE1 (0.38) | BCHEACHEBACE1POLBHTT | |
| SCHEMBL16767465 | 0.76 | BACE1 (0.38) | BCHEACHEBACE1POLBKDM4E | |
| SCHEMBL16767384 | 0.76 | POLB (0.40) | BCHEACHEBACE1POLBHTT | |
| SCHEMBL16767649 | 0.76 | POLB (0.40) | BCHEACHEBACE1POLBHTT | |
| SCHEMBL16767402 | 0.74 | POLB (0.36) | BCHEACHEBACE1POLBHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10244757-B2 | N-cycloalkyl-N-{[2-(1-substitutedcycloalkyl)phenyl]methylene}-(thio)carboxamide derivatives | BAYER CROPSCIENCE AKTIENGESELLSCHAFT (DE) | 2019-04-02 | — | — | US | disclosed |
| US-20190029255-A1 | N-CYCLOALKYL-N-{[2-(1-SUBSTITUTEDCYCLOALKYL)PHENYL]METHYLENE}-(THIO)CARBOXAMIDE DERIVATIVES | BAYER CROPSCIENCE AKTIENGESELLSCHAFT (DE) | 2019-01-31 | — | — | US | disclosed |
| EP-3077378-B1 | N-CYCLOPROPYL-N-{[2-(1-SUBSTITUTEDCYCLOPROPYL)PHENYL]METHYLENE}-(THIO)CARBOXAMIDE DERIVATIVES | BAYER CROPSCIENCE AG (DE) | 2018-11-07 | — | — | EP | disclosed |
| US-10070645-B2 | N-cycloalkyl-N-{[2-(1-substitutedcycloalkyl)phenyl]methylene}-(thio)carboxamide derivatives | BAYER CROPSCIENCE AKTIENGESELLSCHAFT (DE) | 2018-09-11 | — | — | US | disclosed |
| US-10071967-B2 | N-cycloalkyl-N-{[2-(1-substitutedcycloalkyl)phenyl]methylene}-(thio)carboxamide derivatives | BAYER CROPSCIENCE AKTIENGESELLSCHAFT (DE) | 2018-09-11 | — | — | US | disclosed |
| US-20160326120-A1 | N-CYCLOALKYL-N--(THIO)CARBOXAMIDE DERIVATIVES | BAYER CROPSCIENCE AKTIENGESELLSCHAFT (DE) | 2016-11-10 | — | — | US | disclosed |
| US-20160316752-A1 | N-CYCLOALKYL-N--(THIO)CARBOXAMIDE DERIVATIVES | BAYER CROPSCIENCE AKTIENGESELLSCHAFT (DE) | 2016-11-03 | — | — | US | disclosed |
| EP-3077378-A1 | N-CYCLOALKYL-N-{[2-(1-SUBSTITUTEDCYCLOALKYL)PHENYL]METHYLENE}-(THIO)CARBOXAMIDE DERIVATIVES | Bayer CropScience Aktiengesellschaft (DE) | 2016-10-12 | — | — | EP | disclosed |
| EP-3077377-A1 | N-CYCLOALKYL-N-{[2-(1-SUBSTITUTEDCYCLOALKYL)PHENYL]METHYLENE}-(THIO)CARBOXAMIDE DERIVATIVES | Bayer CropScience Aktiengesellschaft (DE) | 2016-10-12 | — | — | EP | disclosed |
| WO-2015082586-A1 | N-CYCLOALKYL-N-{[2-(1-SUBSTITUTEDCYCLOALKYL)PHENYL]METHYLENE}-(THIO)CARBOXAMIDE DERIVATIVES | BAYER CROPSCIENCE AG (DE) | 2015-06-11 | — | — | WO | disclosed |
| WO-2015082587-A1 | N-CYCLOALKYL-N-{[2-(1-SUBSTITUTEDCYCLOALKYL)PHENYL]METHYLENE}-(THIO)CARBOXAMIDE DERIVATIVES | BAYER CROPSCIENCE AG (DE) | 2015-06-11 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10070645-B2 | N-cycloalkyl-N-{[2-(1-substitutedcycloalkyl)phenyl]methylene}-(thio)carboxamide derivatives | CBR3, NAT1, NANP | BCHE 969/4885ACHE 1721/4885BACE1 2709/4885 |
| US-20160316752-A1 | N-CYCLOALKYL-N--(THIO)CARBOXAMIDE DERIVATIVES | CBR3, NANP, CYP51A1 | BCHE 309/4885ACHE 1072/4885BACE1 2597/4885 |
| US-10071967-B2 | N-cycloalkyl-N-{[2-(1-substitutedcycloalkyl)phenyl]methylene}-(thio)carboxamide derivatives | CBR3, NAT1, NANP | BCHE 969/4885ACHE 1721/4885BACE1 2709/4885 |
| US-20160326120-A1 | N-CYCLOALKYL-N--(THIO)CARBOXAMIDE DERIVATIVES | CBR3, NANP, CYP51A1 | BCHE 353/4885ACHE 1127/4885BACE1 2637/4885 |
| US-10244757-B2 | N-cycloalkyl-N-{[2-(1-substitutedcycloalkyl)phenyl]methylene}-(thio)carboxamide derivatives | CBR3, NAT1, NANP | BCHE 969/4885ACHE 1721/4885BACE1 2709/4885 |
| US-20190029255-A1 | N-CYCLOALKYL-N-{[2-(1-SUBSTITUTEDCYCLOALKYL)PHENYL]METHYLENE}-(THIO)CARBOXAMIDE DERIVATIVES | CBR3, NAT1, NANP | BCHE 995/4885ACHE 1662/4885BACE1 2373/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.