Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.40 |
| ▸ | BCHE | P06276 | 2/20 | 0.38 |
| ▸ | ACHE | P22303 | 2/20 | 0.38 |
| ▸ | BACE1 | P56817 | 2/20 | 0.38 |
| ▸ | CXCR3 | P49682 | 2/20 | 0.36 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.34 |
| ▸ | GRM3 | Q14832 | 1/20 | 0.34 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 2/20 | 0.34 |
| ▸ | MEN1 | O00255 | 2/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | GLA | P06280 | 1/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
| ▸ | KDM1A | O60341 | 4/20 | 0.33 |
| ▸ | CARM1 | Q86X55 | 1/20 | 0.33 |
| ▸ | PRMT6 | Q96LA8 | 1/20 | 0.33 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.32 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.32 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16767649 | 0.86 | POLB (0.40) | POLBBCHEACHEBACE1CXCR3 | |
| SCHEMBL16767648 | 0.84 | OPRM1 (0.35) | ACHEBACE1OPRL1KDM1AKCNH2 | |
| SCHEMBL16767402 | 0.81 | POLB (0.36) | POLBBCHEACHEBACE1CXCR3 | |
| SCHEMBL28081464 | 0.80 | KDM1A (0.40) | ACHEBACE1OPRL1KDM1ASLC6A4 | |
| SCHEMBL16767692 | 0.79 | BACE1 (0.40) | POLBBCHEACHEBACE1CXCR3 | |
| SCHEMBL16767574 | 0.77 | BACE1 (0.39) | POLBBCHEACHEBACE1CXCR3 | |
| SCHEMBL16767465 | 0.76 | BACE1 (0.38) | POLBBCHEACHEBACE1CXCR3 | |
| SCHEMBL16767615 | 0.76 | BACE1 (0.38) | POLBBCHEACHEBACE1CXCR3 | |
| SCHEMBL16766969 | 0.76 | BCHE (0.38) | POLBBCHEACHEBACE1CXCR3 | |
| SCHEMBL1039759 | 0.73 | BCHE (0.50) | POLBBCHEACHEBACE1CXCR3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10244757-B2 | N-cycloalkyl-N-{[2-(1-substitutedcycloalkyl)phenyl]methylene}-(thio)carboxamide derivatives | BAYER CROPSCIENCE AKTIENGESELLSCHAFT (DE) | 2019-04-02 | — | — | US | disclosed |
| US-20190029255-A1 | N-CYCLOALKYL-N-{[2-(1-SUBSTITUTEDCYCLOALKYL)PHENYL]METHYLENE}-(THIO)CARBOXAMIDE DERIVATIVES | BAYER CROPSCIENCE AKTIENGESELLSCHAFT (DE) | 2019-01-31 | — | — | US | disclosed |
| EP-3077378-B1 | N-CYCLOPROPYL-N-{[2-(1-SUBSTITUTEDCYCLOPROPYL)PHENYL]METHYLENE}-(THIO)CARBOXAMIDE DERIVATIVES | BAYER CROPSCIENCE AG (DE) | 2018-11-07 | — | — | EP | disclosed |
| US-10071967-B2 | N-cycloalkyl-N-{[2-(1-substitutedcycloalkyl)phenyl]methylene}-(thio)carboxamide derivatives | BAYER CROPSCIENCE AKTIENGESELLSCHAFT (DE) | 2018-09-11 | — | — | US | disclosed |
| US-10070645-B2 | N-cycloalkyl-N-{[2-(1-substitutedcycloalkyl)phenyl]methylene}-(thio)carboxamide derivatives | BAYER CROPSCIENCE AKTIENGESELLSCHAFT (DE) | 2018-09-11 | — | — | US | disclosed |
| US-20160326120-A1 | N-CYCLOALKYL-N--(THIO)CARBOXAMIDE DERIVATIVES | BAYER CROPSCIENCE AKTIENGESELLSCHAFT (DE) | 2016-11-10 | — | — | US | disclosed |
| US-20160316752-A1 | N-CYCLOALKYL-N--(THIO)CARBOXAMIDE DERIVATIVES | BAYER CROPSCIENCE AKTIENGESELLSCHAFT (DE) | 2016-11-03 | — | — | US | disclosed |
| EP-3077378-A1 | N-CYCLOALKYL-N-{[2-(1-SUBSTITUTEDCYCLOALKYL)PHENYL]METHYLENE}-(THIO)CARBOXAMIDE DERIVATIVES | Bayer CropScience Aktiengesellschaft (DE) | 2016-10-12 | — | — | EP | disclosed |
| EP-3077377-A1 | N-CYCLOALKYL-N-{[2-(1-SUBSTITUTEDCYCLOALKYL)PHENYL]METHYLENE}-(THIO)CARBOXAMIDE DERIVATIVES | Bayer CropScience Aktiengesellschaft (DE) | 2016-10-12 | — | — | EP | disclosed |
| WO-2015082587-A1 | N-CYCLOALKYL-N-{[2-(1-SUBSTITUTEDCYCLOALKYL)PHENYL]METHYLENE}-(THIO)CARBOXAMIDE DERIVATIVES | BAYER CROPSCIENCE AG (DE) | 2015-06-11 | — | — | WO | disclosed |
| WO-2015082586-A1 | N-CYCLOALKYL-N-{[2-(1-SUBSTITUTEDCYCLOALKYL)PHENYL]METHYLENE}-(THIO)CARBOXAMIDE DERIVATIVES | BAYER CROPSCIENCE AG (DE) | 2015-06-11 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10070645-B2 | N-cycloalkyl-N-{[2-(1-substitutedcycloalkyl)phenyl]methylene}-(thio)carboxamide derivatives | CBR3, NAT1, NANP | POLB 2964/4885BCHE 969/4885ACHE 1721/4885 |
| US-20160316752-A1 | N-CYCLOALKYL-N--(THIO)CARBOXAMIDE DERIVATIVES | CBR3, NANP, CYP51A1 | POLB 3254/4885BCHE 309/4885ACHE 1072/4885 |
| US-10071967-B2 | N-cycloalkyl-N-{[2-(1-substitutedcycloalkyl)phenyl]methylene}-(thio)carboxamide derivatives | CBR3, NAT1, NANP | POLB 2964/4885BCHE 969/4885ACHE 1721/4885 |
| US-20160326120-A1 | N-CYCLOALKYL-N--(THIO)CARBOXAMIDE DERIVATIVES | CBR3, NANP, CYP51A1 | POLB 3344/4885BCHE 353/4885ACHE 1127/4885 |
| US-10244757-B2 | N-cycloalkyl-N-{[2-(1-substitutedcycloalkyl)phenyl]methylene}-(thio)carboxamide derivatives | CBR3, NAT1, NANP | POLB 2964/4885BCHE 969/4885ACHE 1721/4885 |
| US-20190029255-A1 | N-CYCLOALKYL-N-{[2-(1-SUBSTITUTEDCYCLOALKYL)PHENYL]METHYLENE}-(THIO)CARBOXAMIDE DERIVATIVES | CBR3, NAT1, NANP | POLB 2792/4885BCHE 995/4885ACHE 1662/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.