Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DPP4 | P27487 | 1/20 | 0.32 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.32 |
| ▸ | DPP9 | Q86TI2 | 1/20 | 0.32 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.32 |
| ▸ | HTR2A | P28223 | 1/20 | 0.31 |
| ▸ | HTR2C | P28335 | 1/20 | 0.31 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.31 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.31 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16767316 | 0.87 | KDM1A (0.32) | SIGMAR1 | |
| SCHEMBL16767001 | 0.83 | BACE1 (0.32) | — | |
| SCHEMBL16766554 | 0.82 | SLC6A4 (0.33) | — | |
| SCHEMBL28832545 | 0.80 | MAOA (0.33) | — | |
| SCHEMBL16766351 | 0.77 | — | — | |
| SCHEMBL16767313 | 0.76 | BACE1 (0.38) | DPP4DPP8DPP9DPP7HTR2A | |
| SCHEMBL16766521 | 0.73 | PDK2 (0.35) | HTR2AHTR2C | |
| SCHEMBL28081427 | 0.71 | SLC6A2 (0.33) | DPP4DPP8DPP9DPP7 | |
| Tetrahydrofuran SCHEMBL28085195 | 0.70 | KCNH2 (0.35) | DPP4DPP8DPP9DPP7HTR2A | |
| SCHEMBL30149750 | 0.67 | IDO1 (0.40) | DPP4HTR2AHTR2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10244757-B2 | N-cycloalkyl-N-{[2-(1-substitutedcycloalkyl)phenyl]methylene}-(thio)carboxamide derivatives | BAYER CROPSCIENCE AKTIENGESELLSCHAFT (DE) | 2019-04-02 | — | — | US | disclosed |
| CN-105873907-B | N-cycloalkyl-N- { [2- (1-substituted cycloalkyl) phenyl ] methylene } - (thio) carboxamide derivatives | 拜耳作物科学股份公司 | 2019-03-12 | — | — | CN | disclosed |
| US-20190029255-A1 | N-CYCLOALKYL-N-{[2-(1-SUBSTITUTEDCYCLOALKYL)PHENYL]METHYLENE}-(THIO)CARBOXAMIDE DERIVATIVES | BAYER CROPSCIENCE AKTIENGESELLSCHAFT (DE) | 2019-01-31 | — | — | US | disclosed |
| EP-3077378-B1 | N-CYCLOPROPYL-N-{[2-(1-SUBSTITUTEDCYCLOPROPYL)PHENYL]METHYLENE}-(THIO)CARBOXAMIDE DERIVATIVES | BAYER CROPSCIENCE AG (DE) | 2018-11-07 | — | — | EP | disclosed |
| US-10071967-B2 | N-cycloalkyl-N-{[2-(1-substitutedcycloalkyl)phenyl]methylene}-(thio)carboxamide derivatives | BAYER CROPSCIENCE AKTIENGESELLSCHAFT (DE) | 2018-09-11 | — | — | US | disclosed |
| US-10070645-B2 | N-cycloalkyl-N-{[2-(1-substitutedcycloalkyl)phenyl]methylene}-(thio)carboxamide derivatives | BAYER CROPSCIENCE AKTIENGESELLSCHAFT (DE) | 2018-09-11 | — | — | US | disclosed |
| US-20160326120-A1 | N-CYCLOALKYL-N--(THIO)CARBOXAMIDE DERIVATIVES | BAYER CROPSCIENCE AKTIENGESELLSCHAFT (DE) | 2016-11-10 | — | — | US | disclosed |
| US-20160316752-A1 | N-CYCLOALKYL-N--(THIO)CARBOXAMIDE DERIVATIVES | BAYER CROPSCIENCE AKTIENGESELLSCHAFT (DE) | 2016-11-03 | — | — | US | disclosed |
| EP-3077377-A1 | N-CYCLOALKYL-N-{[2-(1-SUBSTITUTEDCYCLOALKYL)PHENYL]METHYLENE}-(THIO)CARBOXAMIDE DERIVATIVES | Bayer CropScience Aktiengesellschaft (DE) | 2016-10-12 | — | — | EP | disclosed |
| EP-3077378-A1 | N-CYCLOALKYL-N-{[2-(1-SUBSTITUTEDCYCLOALKYL)PHENYL]METHYLENE}-(THIO)CARBOXAMIDE DERIVATIVES | Bayer CropScience Aktiengesellschaft (DE) | 2016-10-12 | — | — | EP | disclosed |
| CN-105873907-A | N-cycloalkyl-N- { [2- (1-substituted cycloalkyl) phenyl ] methylene } - (thio) carboxamide derivatives | 拜耳作物科学股份公司 | 2016-08-17 | — | — | CN | disclosed |
| WO-2015082586-A1 | N-CYCLOALKYL-N-{[2-(1-SUBSTITUTEDCYCLOALKYL)PHENYL]METHYLENE}-(THIO)CARBOXAMIDE DERIVATIVES | BAYER CROPSCIENCE AG (DE) | 2015-06-11 | — | — | WO | disclosed |
| WO-2015082587-A1 | N-CYCLOALKYL-N-{[2-(1-SUBSTITUTEDCYCLOALKYL)PHENYL]METHYLENE}-(THIO)CARBOXAMIDE DERIVATIVES | BAYER CROPSCIENCE AG (DE) | 2015-06-11 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10070645-B2 | N-cycloalkyl-N-{[2-(1-substitutedcycloalkyl)phenyl]methylene}-(thio)carboxamide derivatives | CBR3, NAT1, NANP | DPP4 632/4885DPP8 863/4885DPP9 720/4885 |
| US-20160316752-A1 | N-CYCLOALKYL-N--(THIO)CARBOXAMIDE DERIVATIVES | CBR3, NANP, CYP51A1 | DPP4 471/4885DPP8 500/4885DPP9 507/4885 |
| US-10071967-B2 | N-cycloalkyl-N-{[2-(1-substitutedcycloalkyl)phenyl]methylene}-(thio)carboxamide derivatives | CBR3, NAT1, NANP | DPP4 632/4885DPP8 863/4885DPP9 720/4885 |
| US-20160326120-A1 | N-CYCLOALKYL-N--(THIO)CARBOXAMIDE DERIVATIVES | CBR3, NANP, CYP51A1 | DPP4 580/4885DPP8 606/4885DPP9 659/4885 |
| US-10244757-B2 | N-cycloalkyl-N-{[2-(1-substitutedcycloalkyl)phenyl]methylene}-(thio)carboxamide derivatives | CBR3, NAT1, NANP | DPP4 632/4885DPP8 863/4885DPP9 720/4885 |
| US-20190029255-A1 | N-CYCLOALKYL-N-{[2-(1-SUBSTITUTEDCYCLOALKYL)PHENYL]METHYLENE}-(THIO)CARBOXAMIDE DERIVATIVES | CBR3, NAT1, NANP | DPP4 640/4885DPP8 867/4885DPP9 752/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.