Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDK2 | Q15119 | 8/20 | 0.35 |
| ▸ | SLC5A1 | P13866 | 1/20 | 0.31 |
| ▸ | SLC5A2 | P31639 | 1/20 | 0.31 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19291084 | 0.81 | PDK2 (0.47) | PDK2 | |
| SCHEMBL16766521 | 0.77 | PDK2 (0.35) | PDK2 | |
| SCHEMBL16767601 | 0.76 | PDK2 (0.38) | PDK2P2RX7 | |
| SCHEMBL19743357 | 0.76 | CNR2 (0.38) | PDK2 | |
| SCHEMBL20455827 | 0.75 | PDK2 (0.43) | PDK2 | |
| SCHEMBL16767546 | 0.74 | KMT2A (0.37) | P2RX7 | |
| SCHEMBL19205328 | 0.72 | PDK2 (0.46) | PDK2 | |
| SCHEMBL21587746 | 0.71 | OPRL1 (0.44) | — | |
| SCHEMBL21543242 | 0.71 | PDK2 (0.44) | PDK2 | |
| SCHEMBL21543374 | 0.71 | PDK2 (0.43) | PDK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10244757-B2 | N-cycloalkyl-N-{[2-(1-substitutedcycloalkyl)phenyl]methylene}-(thio)carboxamide derivatives | BAYER CROPSCIENCE AKTIENGESELLSCHAFT (DE) | 2019-04-02 | — | — | US | disclosed |
| CN-105873907-B | N-cycloalkyl-N- { [2- (1-substituted cycloalkyl) phenyl ] methylene } - (thio) carboxamide derivatives | 拜耳作物科学股份公司 | 2019-03-12 | — | — | CN | disclosed |
| US-20190029255-A1 | N-CYCLOALKYL-N-{[2-(1-SUBSTITUTEDCYCLOALKYL)PHENYL]METHYLENE}-(THIO)CARBOXAMIDE DERIVATIVES | BAYER CROPSCIENCE AKTIENGESELLSCHAFT (DE) | 2019-01-31 | — | — | US | disclosed |
| EP-3077378-B1 | N-CYCLOPROPYL-N-{[2-(1-SUBSTITUTEDCYCLOPROPYL)PHENYL]METHYLENE}-(THIO)CARBOXAMIDE DERIVATIVES | BAYER CROPSCIENCE AG (DE) | 2018-11-07 | — | — | EP | disclosed |
| US-10071967-B2 | N-cycloalkyl-N-{[2-(1-substitutedcycloalkyl)phenyl]methylene}-(thio)carboxamide derivatives | BAYER CROPSCIENCE AKTIENGESELLSCHAFT (DE) | 2018-09-11 | — | — | US | disclosed |
| US-10070645-B2 | N-cycloalkyl-N-{[2-(1-substitutedcycloalkyl)phenyl]methylene}-(thio)carboxamide derivatives | BAYER CROPSCIENCE AKTIENGESELLSCHAFT (DE) | 2018-09-11 | — | — | US | disclosed |
| US-20160326120-A1 | N-CYCLOALKYL-N--(THIO)CARBOXAMIDE DERIVATIVES | BAYER CROPSCIENCE AKTIENGESELLSCHAFT (DE) | 2016-11-10 | — | — | US | disclosed |
| US-20160316752-A1 | N-CYCLOALKYL-N--(THIO)CARBOXAMIDE DERIVATIVES | BAYER CROPSCIENCE AKTIENGESELLSCHAFT (DE) | 2016-11-03 | — | — | US | disclosed |
| EP-3077377-A1 | N-CYCLOALKYL-N-{[2-(1-SUBSTITUTEDCYCLOALKYL)PHENYL]METHYLENE}-(THIO)CARBOXAMIDE DERIVATIVES | Bayer CropScience Aktiengesellschaft (DE) | 2016-10-12 | — | — | EP | disclosed |
| EP-3077378-A1 | N-CYCLOALKYL-N-{[2-(1-SUBSTITUTEDCYCLOALKYL)PHENYL]METHYLENE}-(THIO)CARBOXAMIDE DERIVATIVES | Bayer CropScience Aktiengesellschaft (DE) | 2016-10-12 | — | — | EP | disclosed |
| WO-2015082587-A1 | N-CYCLOALKYL-N-{[2-(1-SUBSTITUTEDCYCLOALKYL)PHENYL]METHYLENE}-(THIO)CARBOXAMIDE DERIVATIVES | BAYER CROPSCIENCE AG (DE) | 2015-06-11 | — | — | WO | disclosed |
| WO-2015082586-A1 | N-CYCLOALKYL-N-{[2-(1-SUBSTITUTEDCYCLOALKYL)PHENYL]METHYLENE}-(THIO)CARBOXAMIDE DERIVATIVES | BAYER CROPSCIENCE AG (DE) | 2015-06-11 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10070645-B2 | N-cycloalkyl-N-{[2-(1-substitutedcycloalkyl)phenyl]methylene}-(thio)carboxamide derivatives | CBR3, NAT1, NANP | PDK2 2128/4885SLC5A1 3797/4885SLC5A2 3028/4885 |
| US-20160316752-A1 | N-CYCLOALKYL-N--(THIO)CARBOXAMIDE DERIVATIVES | CBR3, NANP, CYP51A1 | PDK2 2526/4885SLC5A1 3963/4885SLC5A2 3208/4885 |
| US-10071967-B2 | N-cycloalkyl-N-{[2-(1-substitutedcycloalkyl)phenyl]methylene}-(thio)carboxamide derivatives | CBR3, NAT1, NANP | PDK2 2128/4885SLC5A1 3797/4885SLC5A2 3028/4885 |
| US-20160326120-A1 | N-CYCLOALKYL-N--(THIO)CARBOXAMIDE DERIVATIVES | CBR3, NANP, CYP51A1 | PDK2 2463/4885SLC5A1 3911/4885SLC5A2 3209/4885 |
| US-10244757-B2 | N-cycloalkyl-N-{[2-(1-substitutedcycloalkyl)phenyl]methylene}-(thio)carboxamide derivatives | CBR3, NAT1, NANP | PDK2 2128/4885SLC5A1 3797/4885SLC5A2 3028/4885 |
| US-20190029255-A1 | N-CYCLOALKYL-N-{[2-(1-SUBSTITUTEDCYCLOALKYL)PHENYL]METHYLENE}-(THIO)CARBOXAMIDE DERIVATIVES | CBR3, NAT1, NANP | PDK2 2007/4885SLC5A1 3705/4885SLC5A2 3018/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.