Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 5/20 | 0.51 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.51 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.51 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.51 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.51 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.51 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.47 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.47 |
| ▸ | HTT | P42858 | 2/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 3/20 | 0.45 |
| ▸ | ATM | Q13315 | 1/20 | 0.45 |
| ▸ | UBE2T | Q9NPD8 | 1/20 | 0.45 |
| ▸ | ASIC3 | Q9UHC3 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.45 |
| ▸ | PDE10A | Q9Y233 | 2/20 | 0.44 |
| ▸ | SLC13A5 | Q86YT5 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16133681 | 0.84 | SMN1; SMN2 (0.53) | HPGDCYP1A2CYP2C19HSD17B10CYP3A4 | |
| SCHEMBL17050824 | 0.79 | SMN1; SMN2 (0.57) | HPGDCYP1A2CYP2C19SMN1; SMN2ALOX15 | |
| SCHEMBL16136346 | 0.77 | HPGD (0.55) | HPGDCYP1A2CYP2C19HSD17B10SMN1; SMN2 | |
| SCHEMBL7435843 | 0.76 | UBE2T (0.56) | HPGDCYP1A2CYP2C19HSD17B10CYP3A4 | |
| SCHEMBL18381211 | 0.75 | SLC13A5 (0.56) | HPGDCYP1A2CYP2C19HSD17B10CYP3A4 | |
| SCHEMBL11683409 | 0.75 | CA12 (0.50) | HPGDCYP1A2CYP2C19HSD17B10CYP3A4 | |
| SCHEMBL17481133 | 0.74 | HPGD (0.69) | HPGDCYP1A2CYP2C19HSD17B10CYP3A4 | |
| SCHEMBL23374667 | 0.74 | UBE2T (0.53) | HPGDCYP1A2CYP2C19HSD17B10CYP3A4 | |
| SCHEMBL19372016 | 0.74 | UBE2T (0.70) | HPGDCYP1A2CYP2C19HSD17B10CYP3A4 | |
| SCHEMBL24198727 | 0.73 | HPGD (0.63) | HPGDCYP1A2CYP2C19HSD17B10CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9776996-B2 | Substituted 6,5-fused bicyclic heteroaryl compounds | Epizyme, Inc. (US) | 2017-10-03 | — | — | US | disclosed |
| US-9045477-B2 | Substituted 6,5-fused bicyclic heteroaryl compounds | Epizyme, Inc. (US) | 2015-06-02 | — | — | US | disclosed |