Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.57 |
| ▸ | HTT | P42858 | 3/20 | 0.57 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.57 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.57 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.57 |
| ▸ | HPGD | P15428 | 4/20 | 0.56 |
| ▸ | RAB9A | P51151 | 2/20 | 0.56 |
| ▸ | MAPT | P10636 | 6/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.54 |
| ▸ | NPC1 | O15118 | 1/20 | 0.54 |
| ▸ | POLB | P06746 | 3/20 | 0.54 |
| ▸ | ATM | Q13315 | 1/20 | 0.54 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.54 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.54 |
| ▸ | GAA | P10253 | 2/20 | 0.53 |
| ▸ | LMNA | P02545 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.52 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.52 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16136346 | 0.86 | HPGD (0.55) | SMN1; SMN2HTTCYP1A2ALOX15CYP2C19 | |
| SCHEMBL27452722 | 0.85 | HPGD (0.64) | SMN1; SMN2HTTCYP1A2ALOX15CYP2C19 | |
| SCHEMBL16133681 | 0.85 | SMN1; SMN2 (0.53) | SMN1; SMN2HTTCYP1A2ALOX15CYP2C19 | |
| SCHEMBL17481133 | 0.83 | HPGD (0.69) | SMN1; SMN2HTTCYP1A2ALOX15CYP2C19 | |
| SCHEMBL11590976 | 0.80 | HPGD (0.68) | SMN1; SMN2HTTCYP1A2ALOX15CYP2C19 | |
| SCHEMBL7435843 | 0.80 | UBE2T (0.56) | SMN1; SMN2HTTCYP1A2ALOX15CYP2C19 | |
| SCHEMBL16768664 | 0.79 | HPGD (0.51) | SMN1; SMN2HTTCYP1A2ALOX15CYP2C19 | |
| SCHEMBL17500055 | 0.79 | HTT (0.71) | SMN1; SMN2HTTCYP1A2ALOX15CYP2C19 | |
| SCHEMBL18381211 | 0.79 | SLC13A5 (0.56) | SMN1; SMN2HTTCYP1A2ALOX15CYP2C19 | |
| SCHEMBL18381451 | 0.79 | SMN1; SMN2 (0.53) | SMN1; SMN2HTTALOX15HPGDRAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9365570-B2 | Substituted 6, 5-fused bicyclic heteroaryl compounds | Epizyme, Inc. (US) | 2016-06-14 | — | — | US | disclosed |
| US-20150246916-A1 | Substituted 6, 5-Fused Bicyclic Heteroaryl Compounds | Epizyme, Inc. | 2015-09-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150246916-A1 | Substituted 6, 5-Fused Bicyclic Heteroaryl Compounds | CYP3A5, PAICS, CYP4B1 | SMN1; SMN2 4624/4885HTT 906/4885CYP1A2 36/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.