Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 11/20 | 0.53 |
| ▸ | HDAC2 | Q92769 | 11/20 | 0.53 |
| ▸ | HDAC3 | O15379 | 5/20 | 0.52 |
| ▸ | HDAC8 | Q9BY41 | 3/20 | 0.52 |
| ▸ | HDAC6 | Q9UBN7 | 3/20 | 0.52 |
| ▸ | HDAC11 | Q96DB2 | 2/20 | 0.52 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.52 |
| ▸ | ABCB1 | P08183 | 4/20 | 0.50 |
| ▸ | ABCC1 | P33527 | 4/20 | 0.50 |
| ▸ | MME | P08473 | 2/20 | 0.48 |
| ▸ | ACE | P12821 | 2/20 | 0.48 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.47 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16768804 | 0.88 | HDAC1 (0.48) | HDAC1HDAC2HDAC3HDAC8HDAC6 | |
| SCHEMBL16770399 | 0.76 | MME (0.67) | MMEACE | |
| SCHEMBL18175795 | 0.76 | MME (0.48) | MMEACE | |
| SCHEMBL16768805 | 0.74 | MME (0.61) | MMEACE | |
| SCHEMBL27966840 | 0.71 | HDAC1 (0.80) | HDAC1HDAC2HDAC3HDAC8HDAC6 | |
| SCHEMBL15549699 | 0.71 | ABCB1 (0.77) | HDAC1HDAC2HDAC3HDAC8HDAC6 | |
| SCHEMBL2037118 | 0.71 | ABCB1 (0.76) | HDAC1HDAC2HDAC3HDAC8HDAC6 | |
| SCHEMBL13055302 | 0.71 | ABCB1 (0.83) | HDAC1HDAC2HDAC3HDAC8HDAC6 | |
| SCHEMBL2205081 | 0.70 | HDAC1 (0.80) | HDAC1HDAC2HDAC3HDAC8HDAC6 | |
| SCHEMBL2762787 | 0.70 | ABCB1 (0.78) | HDAC1HDAC2HDAC3HDAC8HDAC6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9045443-B2 | Nitric oxide donor neprilysin inhibitors | THERAVANCE BIOPHARMA R&D IP, LLC (US) | 2015-06-02 | — | — | US | disclosed |