Predicted protein targets (top 2)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MME | P08473 | 20/20 | 0.48 |
| ▸ | ACE | P12821 | 10/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16770399 | 0.76 | MME (0.67) | MMEACE | |
| SCHEMBL16768806 | 0.76 | HDAC1 (0.53) | MMEACE | |
| SCHEMBL16768805 | 0.72 | MME (0.61) | MMEACE | |
| SCHEMBL14890376 | 0.68 | MME (1.00) | MMEACE | |
| SCHEMBL14900565 | 0.68 | MME (1.00) | MMEACE | |
| SCHEMBL14890685 | 0.67 | MME (0.74) | MMEACE | |
| SCHEMBL18597847 | 0.67 | MME (0.74) | MMEACE | |
| SCHEMBL16768804 | 0.65 | HDAC1 (0.48) | MME | |
| SCHEMBL16770404 | 0.64 | MME (0.60) | MME | |
| SCHEMBL16770396 | 0.64 | CTSS (0.49) | MMEACE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2855464-B1 | NITRIC OXIDE DONOR NEPRILYSIN INHIBITORS | THERAVANCE BIOPHARMA R&D IP LLC (US) | 2016-10-26 | — | — | EP | disclosed |