Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE | P22303 | 3/20 | 0.45 |
| ▸ | JAK2 | O60674 | 14/20 | 0.42 |
| ▸ | JAK1 | P23458 | 14/20 | 0.42 |
| ▸ | TYK2 | P29597 | 14/20 | 0.42 |
| ▸ | JAK3 | P52333 | 14/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | NOS1 | P29475 | 1/20 | 0.35 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12460153 | 0.90 | PDK2 (0.40) | ACHEJAK2JAK1TYK2JAK3 | |
| SCHEMBL15703086 | 0.88 | ACHE (0.50) | ACHEJAK2JAK1TYK2JAK3 | |
| SCHEMBL25974815 | 0.84 | ACHE (0.41) | ACHEJAK2JAK1TYK2JAK3 | |
| SCHEMBL13738735 | 0.80 | ACHE (0.44) | ACHEJAK2JAK1TYK2JAK3 | |
| SCHEMBL14329354 | 0.79 | ACHE (0.40) | ACHEJAK2JAK1TYK2JAK3 | |
| SCHEMBL19159430 | 0.79 | ACHE (0.40) | ACHEJAK2JAK1TYK2JAK3 | |
| SCHEMBL30911116 | 0.77 | JAK2 (0.39) | ACHEJAK2JAK1TYK2JAK3 | |
| SCHEMBL12093438 | 0.77 | JAK2 (0.39) | ACHEJAK2JAK1TYK2JAK3 | |
| SCHEMBL19121899 | 0.75 | ACHE (0.51) | ACHEJAK2JAK1TYK2JAK3 | |
| SCHEMBL15431451 | 0.75 | ACHE (0.41) | ACHENOS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2345629-B1 | FLUORENE COMPOUND AND USE THEREOF FOR MEDICAL PURPOSES | JAPAN TOBACCO INC (JP) | 2015-06-03 | — | — | EP | disclosed |