Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CXCR2 | P25025 | 5/20 | 0.38 |
| ▸ | HSP90AA1 | P07900 | 2/20 | 0.35 |
| ▸ | HSP90AB1 | P08238 | 2/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | ALPL | P05186 | 6/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.32 |
| ▸ | BACE1 | P56817 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3289934 | 0.86 | CXCR2 (0.40) | CXCR2HSP90AA1HSP90AB1LMNAALPL | |
| SCHEMBL1676226 | 0.85 | CXCR2 (0.47) | CXCR2HSP90AA1HSP90AB1LMNAL3MBTL1 | |
| SCHEMBL2867224 | 0.78 | CXCR2 (0.43) | CXCR2HSP90AA1HSP90AB1LMNAALPL | |
| SCHEMBL31305442 | 0.78 | CXCR2 (0.43) | CXCR2HSP90AA1HSP90AB1LMNAALPL | |
| SCHEMBL31376139 | 0.78 | ALPL (0.43) | HSP90AA1HSP90AB1LMNAALPLSMN1; SMN2 | |
| SCHEMBL1676901 | 0.77 | EGFR (0.41) | CXCR2HSP90AA1HSP90AB1NPC1CYP1A2 | |
| SCHEMBL1480745 | 0.77 | CXCR2 (0.49) | CXCR2HSP90AA1HSP90AB1LMNAL3MBTL1 | |
| SCHEMBL31305465 | 0.74 | ADORA2A (0.40) | CXCR2HSP90AA1HSP90AB1LMNAALPL | |
| SCHEMBL26111159 | 0.74 | ADORA2A (0.40) | CXCR2HSP90AA1HSP90AB1LMNAALPL | |
| SCHEMBL26111366 | 0.74 | HSP90AA1 (0.41) | CXCR2HSP90AA1HSP90AB1LMNAALPL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110092553-A1 | Substituted Azole Derivatives, Compositions, and Methods of Use | TRANSTECH PHARMA, INC. (US) | 2011-04-21 | — | — | US | disclosed |
| EP-1730118-A1 | SUBSTITUTED AZOLE DERIVATIVES, COMPOSITIONS, AND METHODS OF USE | Transtech Pharma, Inc. (US) | 2006-12-13 | — | — | EP | disclosed |
| WO-2005080346-A1 | SUBSTITUTED AZOLE DERIVATIVES, COMPOSITIONS, AND METHODS OF USE | TRANSTECH PHARMA, INC. (US) | 2005-09-01 | — | — | WO | disclosed |
| US-20050187277-A1 | Substituted azole derivatives, compositions, and methods of use | TRANSTECH PHARMA, INC. | 2005-08-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110092553-A1 | Substituted Azole Derivatives, Compositions, and Methods of Use | PTPRO, PTPN5, PTPRE | CXCR2 2502/4885HSP90AA1 3076/4885HSP90AB1 2732/4885 |
| US-20050187277-A1 | Substituted azole derivatives, compositions, and methods of use | PTPRO, PTPN5, PTPRE | CXCR2 2502/4885HSP90AA1 3076/4885HSP90AB1 2732/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.