Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 2/20 | 0.59 |
| ▸ | LMNA | P02545 | 1/20 | 0.59 |
| ▸ | HTT | P42858 | 1/20 | 0.59 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | IDO1 | P14902 | 2/20 | 0.39 |
| ▸ | TDO2 | P48775 | 1/20 | 0.39 |
| ▸ | RORC | P51449 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2632875 | 1.00 | TP53 (0.59) | TP53LMNAHTTTSHRMEN1 | |
| SCHEMBL17069212 | 1.00 | TP53 (0.59) | TP53LMNAHTTTSHRMEN1 | |
| SCHEMBL20365885 | 0.84 | TP53 (0.55) | TP53LMNAHTTMEN1KMT2A | |
| SCHEMBL19539103 | 0.83 | HTT (0.44) | TP53LMNAHTTTSHRMEN1 | |
| SCHEMBL681524 | 0.83 | TP53 (0.59) | TP53LMNAHTTTSHRMEN1 | |
| SCHEMBL18928638 | 0.82 | HTT (0.42) | TP53LMNAHTTTSHRMEN1 | |
| SCHEMBL13180776 | 0.82 | LMNA (0.39) | TP53LMNAHTTTSHRMEN1 | |
| SCHEMBL28926872 | 0.82 | TP53 (0.62) | TP53LMNAHTTTSHRMEN1 | |
| SCHEMBL8934270 | 0.82 | TP53 (0.57) | TP53LMNAHTTTSHRMEN1 | |
| SCHEMBL9593590 | 0.81 | LMNA (0.52) | TP53LMNAHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2015078374-A1 | SUBSTITUTED BENZAMIDES AND METHODS OF USE THEREOF | GENENTECH, INC. (US) | 2015-06-04 | — | — | WO | disclosed |