Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 20/20 | 0.86 |
| ▸ | BRD2 | P25440 | 20/20 | 0.86 |
| ▸ | BRD3 | Q15059 | 20/20 | 0.86 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.85 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.85 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.85 |
| ▸ | TRIM24 | O15164 | 1/20 | 0.85 |
| ▸ | TAF1 | P21675 | 1/20 | 0.85 |
| ▸ | EP300 | Q09472 | 1/20 | 0.85 |
| ▸ | BRDT | Q58F21 | 1/20 | 0.85 |
| ▸ | PBRM1 | Q86U86 | 1/20 | 0.85 |
| ▸ | TAF1L | Q8IZX4 | 1/20 | 0.85 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.85 |
| ▸ | BRWD1 | Q9NSI6 | 1/20 | 0.85 |
| ▸ | TRIM33 | Q9UPN9 | 1/20 | 0.85 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.69 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26487028 | 0.92 | BRD4 (1.00) | BRD4BRD2BRD3CYP3A4CYP2C9 | |
| SCHEMBL26487039 | 0.92 | BRD4 (1.00) | BRD4BRD2BRD3CYP3A4CYP2C9 | |
| SCHEMBL26487036 | 0.92 | BRD4 (1.00) | BRD4BRD2BRD3CYP3A4CYP2C9 | |
| SCHEMBL26487023 | 0.92 | BRD4 (1.00) | BRD4BRD2BRD3CYP3A4CYP2C9 | |
| SCHEMBL11978838 | 0.92 | BRD4 (1.00) | BRD4BRD2BRD3CYP3A4CYP2C9 | |
| SCHEMBL1907498 | 0.92 | BRD4 (1.00) | BRD4BRD2BRD3CYP3A4CYP2C9 | |
| SCHEMBL1906368 | 0.92 | BRD4 (1.00) | BRD4BRD2BRD3CYP3A4CYP2C9 | |
| SCHEMBL22704705 | 0.92 | BRD4 (1.00) | BRD4BRD2BRD3CYP3A4CYP2C9 | |
| SCHEMBL11978889 | 0.92 | BRD4 (1.00) | BRD4BRD2BRD3CYP3A4CYP2C9 | |
| SCHEMBL29520173 | 0.92 | BRD4 (1.00) | BRD4BRD2BRD3CYP3A4CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023242597-A1 | BIFUNCTIONAL MOLECULES FOR TARGETED PROTEIN DEGRADATION | AMPHISTA THERAPEUTICS LIMITED (GB) | 2023-12-21 | — | — | WO | disclosed |
| WO-2022129925-A1 | NOVEL BIFUNCTIONAL MOLECULES FOR TARGETED PROTEIN DEGRADATION | AMPHISTA THERAPEUTICS LIMITED (GB) | 2022-06-23 | — | — | WO | disclosed |
| WO-2015081284-A1 | BIVALENT BROMODOMAIN LIGANDS, AND METHODS OF USING SAME | COFERON, INC. (US) | 2015-06-04 | — | — | WO | disclosed |