SCHEMBL1906368

SCHEMBL1906368

CC(=O)N1c2ccc(-c3ccc(C(=O)O)cc3)cc2[C@H](Nc2ccc(Cl)cc2)C[C@@H]1C

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
BRD4 O60885 20/20 1.00
BRD2 P25440 18/20 1.00
BRD3 Q15059 18/20 1.00
TRIM24 O15164 1/20 1.00
CYP3A4 P08684 1/20 1.00
CYP2C9 P11712 1/20 1.00
TAF1 P21675 1/20 1.00
CYP2C19 P33261 1/20 1.00
EP300 Q09472 1/20 1.00
BRDT Q58F21 1/20 1.00
PBRM1 Q86U86 1/20 1.00
TAF1L Q8IZX4 1/20 1.00
CREBBP Q92793 1/20 1.00
BRWD1 Q9NSI6 1/20 1.00
TRIM33 Q9UPN9 1/20 1.00

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL11978889 1.00 BRD4 (1.00) BRD4BRD2BRD3TRIM24CYP3A4
SCHEMBL1907498 1.00 BRD4 (1.00) BRD4BRD2BRD3TRIM24CYP3A4
SCHEMBL29520173 1.00 BRD4 (1.00) BRD4BRD2BRD3TRIM24CYP3A4
SCHEMBL22704705 1.00 BRD4 (1.00) BRD4BRD2BRD3TRIM24CYP3A4
SCHEMBL19985767 0.93 BRD4 (0.87) BRD4BRD2BRD3TRIM24CYP3A4
SCHEMBL16774251 0.92 BRD4 (0.85) BRD4BRD2BRD3TRIM24CYP3A4
SCHEMBL16774302 0.92 BRD4 (0.86) BRD4BRD2BRD3TRIM24CYP3A4
SCHEMBL223735 0.92 BRD4 (0.85) BRD4BRD2BRD3TRIM24CYP3A4
SCHEMBL15981317 0.92 BRD4 (0.85) BRD4BRD2BRD3TRIM24CYP3A4
SCHEMBL221384 0.92 BRD4 (0.85) BRD4BRD2BRD3TRIM24CYP3A4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 324 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-12564559-B2 Combinations of LSD1 inhibitors for use in the treatment of solid tumors ORYZON GENOMICS, S.A. (ES) 2026-03-03 US claimed
EP-4684836-A2 COMBINATIONS OF LSD1 INHIBITORS FOR USE IN THE TREATMENT OF NEOPLASTIC DISEASES Oryzon Genomics, S.A. (ES) 2026-01-28 EP claimed
EP-3429571-B1 COMBINATIONS OF LSD1 INHIBITORS FOR USE IN THE TREATMENT OF NEOPLASTIC DISEASES ORYZON GENOMICS SA (ES) 2025-10-08 EP claimed
CN-119874724-A Novel recruitment element of ubiquitin ligase and application thereof 深圳领济生物科技有限公司 2025-04-25 CN claimed
US-20250116671-A1 Kinase Activity In Tumors INSTITUTE FOR CANCER RES D/B/A THE RES INSTITUTE OF FOX CHASE CANCER CENTER (US) 2025-04-10 US claimed
WO-2025059442-A1 MODULATING PLANT RESPONSES TO STRESS AND GROWTH WITH CHEMICALS REMOTE EPIGENETICS INC. (US) 2025-03-20 WO claimed
US-20240264151-A1 Methods and Compositions for Treating Diseases Associated with Exhausted T Cells UNIV PENNSYLVANIA (US) 2024-08-08 US claimed
CN-117159715-A New use of inhibitor and inhibitor screening model 中国农业大学 2023-12-05 CN claimed
EP-3468559-B1 METHODS OF USE AND PHARMACEUTICAL COMBINATIONS OF HDAC INHIBITORS WITH BET INHIBITORS DANA FARBER CANCER INST INC (US) 2023-11-22 EP claimed
US-20230330238-A1 CHIMERIC CONJUGATES FOR DEGRADATION OF VIRAL AND HOST PROTEINS AND METHODS OF USE DANA-FARBER CANCER INSTITUTE, INC. 2023-10-19 US claimed
US-20220047596-A1 COMBINATION OF PARP INHIBITOR AND BRD4 INHIBITOR FOR THE TREATMENT OF CANCER BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (US) 2022-02-17 US claimed
US-20180346988-A1 ZNF532 FOR DIAGNOSIS AND TREATMENT OF CANCER THE BRIGHAM AND WOMEN'S HOSPITAL, INC. (US) 2018-12-06 US claimed
US-20170007595-A1 NSD3 INHIBITORS FOR TREATMENT OF CANCERS THE BRIGHAM AND WOMEN'S HOSPITAL, INC. (US) 2017-01-12 US claimed
WO-2016179222-A1 ZNF532 FOR DIAGNOSIS AND TREATMENT OF CANCER THE BRIGHAM AND WOMEN'S HOSPITAL, INC. (US) 2016-11-10 WO claimed
WO-2015112809-A2 NSD3 INHIBITORS FOR TREATMENT OF CANCERS THE BRIGHAM AND WOMEN'S HOSPITAL, INC. (US) 2015-07-30 WO claimed
EP-2699550-B1 TETRAHYDROQUINOLINE DERIVATIVES USEFUL AS BROMODOMAIN INHIBITORS GLAXOSMITHKLINE LLC (US) 2015-06-10 EP claimed
EP-2496235-A1 BROMODOMAIN INHIBITORS FOR TREATING AUTOIMMUNE AND INFLAMMATORY DISEASES GlaxoSmithKline LLC (US) 2012-09-12 EP claimed
US-20120208800-A1 Bromodomain Inhibitors For Treating Autoimmune And Inflammatory Diseases GLAXOSMITHKLINE LLC 2012-08-16 US claimed
US-20120208814-A1 Thetrahydroquinolines Derivatives As Bromodomain Inhibitors GLAXOSMITHKLINE LLC 2012-08-16 US claimed
WO-2011054843-A1 BROMODOMAIN INHIBITORS FOR TREATING AUTOIMMUNE AND INFLAMMATORY DISEASES GLAXOSMITHKLINE LLC (US) 2011-05-12 WO claimed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20120208814-A1 Thetrahydroquinolines Derivatives As Bromodomain Inhibitors BRD4, BRDT, BRPF3 BRD4 1/4885BRD2 5/4885BRD3 4/4885
US-20120208800-A1 Bromodomain Inhibitors For Treating Autoimmune And Inflammatory Diseases BRD4, BRD3, BRPF3 BRD4 1/4885BRD2 4/4885BRD3 2/4885
US-12564559-B2 Combinations of LSD1 inhibitors for use in the treatment of solid tumors EZH2, BRDT, DOT1L BRD4 17/4885BRD2 46/4885BRD3 25/4885
US-20170007595-A1 NSD3 INHIBITORS FOR TREATMENT OF CANCERS NSD3, NSD2, BRD3 BRD4 5/4885BRD2 15/4885BRD3 3/4885
US-20230330238-A1 CHIMERIC CONJUGATES FOR DEGRADATION OF VIRAL AND HOST PROTEINS AND METHODS OF USE MDM2, TP53, USP19 BRD4 50/4885BRD2 103/4885BRD3 69/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.