Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 1/20 | 0.44 |
| ▸ | APP | P05067 | 1/20 | 0.41 |
| ▸ | PIK3C3 | Q8NEB9 | 1/20 | 0.40 |
| ▸ | BRAF | P15056 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.32 |
| ▸ | PRKCI | P41743 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.31 |
| ▸ | FAAH | O00519 | 1/20 | 0.31 |
| ▸ | QPCT | Q16769 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | RAD52 | P43351 | 1/20 | 0.31 |
| ▸ | ACKR3 | P25106 | 1/20 | 0.30 |
| ▸ | SYK | P43405 | 1/20 | 0.30 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.30 |
| ▸ | FEN1 | P39748 | 1/20 | 0.30 |
| ▸ | NAMPT | P43490 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4400758 | 0.81 | BRD4 (0.44) | BRD4APPPIK3C3BRAFKDM4E | |
| SCHEMBL14637827 | 0.79 | CDK8 (0.40) | BRD4APPPIK3C3BRAFKDM4E | |
| SCHEMBL14637826 | 0.79 | BRD4 (0.39) | BRD4APPPIK3C3BRAFKDM4E | |
| SCHEMBL19682171 | 0.77 | BRD4 (0.41) | BRD4APPPIK3C3BRAFKDM4E | |
| SCHEMBL24600122 | 0.74 | BRD4 (0.44) | BRD4APPPIK3C3KDM4EALDH1A1 | |
| SCHEMBL28007340 | 0.73 | FGFR1 (0.39) | BRD4APPPIK3C3MAPK1SYK | |
| SCHEMBL15058223 | 0.72 | AHR (0.47) | BRD4APPPIK3C3KDM4EALDH1A1 | |
| SCHEMBL28036822 | 0.72 | QPCTL (0.40) | BRD4 | |
| SCHEMBL1269027 | 0.71 | TYR (0.45) | BRD4APPPIK3C3KDM4EALDH1A1 | |
| SCHEMBL15058364 | 0.71 | AHR (0.45) | BRD4APPPIK3C3BRAFKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2734516-B1 | ARYLPYRAZOLE ETHERS AS INHIBITORS OF LEUKOTRIENE A4 HYDROLASE | BOEHRINGER INGELHEIM INT (DE) | 2015-06-17 | — | — | EP | claimed |