Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 9/20 | 0.42 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.42 |
| ▸ | WNT3A | P56704 | 7/20 | 0.41 |
| ▸ | ABL1 | P00519 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16776048 | 0.88 | ABL1 (0.35) | MAPK1HCRTR1ABL1 | |
| SCHEMBL16776231 | 0.86 | ABL1 (0.38) | MAPK1WNT3AABL1 | |
| SCHEMBL16776203 | 0.86 | ABL1 (0.36) | MAPK1WNT3AABL1 | |
| SCHEMBL19365654 | 0.84 | HCRTR1 (0.44) | MAPK1HCRTR1WNT3AABL1 | |
| SCHEMBL16776284 | 0.83 | ABL1 (0.36) | MAPK1WNT3AABL1 | |
| SCHEMBL16776028 | 0.82 | FGFR4 (0.38) | MAPK1WNT3AABL1 | |
| SCHEMBL16776233 | 0.80 | DYRK1A (0.34) | MAPK1WNT3AABL1 | |
| SCHEMBL16776228 | 0.79 | NOTUM (0.38) | MAPK1WNT3A | |
| SCHEMBL17618513 | 0.78 | HCRTR1 (0.42) | MAPK1HCRTR1WNT3AABL1 | |
| SCHEMBL16776014 | 0.78 | GRM5 (0.40) | WNT3AABL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20150152108-A1 | SUBSTITUTED BRIDGED UREA ANALOGS AS SIRTUIN MODULATORS | GLAXOSMITHKLINE LLC | 2015-06-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150152108-A1 | SUBSTITUTED BRIDGED UREA ANALOGS AS SIRTUIN MODULATORS | SIRT1, SIRT3, SIRT2 | MAPK1 2404/4885HCRTR1 2303/4885WNT3A 4291/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.